Kim Brian S
Division of Dermatology, Department of Medicine, Center for the Study of Itch, Washington University School of Medicine, St. Louis, Missouri, USA.
J Invest Dermatol. 2015 Mar;135(3):673-678. doi: 10.1038/jid.2014.401. Epub 2014 Oct 23.
Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions. Finally, we address how these studies have informed our understanding of the regulation of ILCs and the therapeutic potential of targeting these cells in the context of skin inflammation.
固有淋巴细胞(ILCs)是固有免疫细胞异质性家族的一部分,在介导免疫、组织稳态和病理性炎症方面具有新确定的作用。在此,我们综述了近期关于阐明ILCs在多种炎症性皮肤病发病机制中的作用及其独特效应功能的研究。最后,我们探讨了这些研究如何增进我们对ILCs调节的理解以及在皮肤炎症背景下靶向这些细胞的治疗潜力。