Thoraxcenter, Erasmus, Rotterdam, the Netherlands.
Thoraxcenter, Erasmus, Rotterdam, the Netherlands.
JACC Cardiovasc Imaging. 2014 Nov;7(11):1130-48. doi: 10.1016/j.jcmg.2014.06.018. Epub 2014 Nov 10.
Bioresorbable vascular scaffolds (BRS) represent a novel approach to provide transient vessel support to drug-delivery capability without the long-term limitations of metallic drug-eluting stents (DES). The technology has the potential to overcome many of the safety concerns associated with metallic DES and possibly even convey further clinical benefit. In particular, the BRS are designed to provide short-term lumen support, and after being completely bioresorbed, eliminate the permanent caging typical of metallic DES. However, this technology has required new imaging modalities and methodologies for its assessment because the design, degradation rate, loss of mechanical property, and drug deliverability may affect its safety and efficacy. We provide an overview of all existing methods for assessing bioresorbable devices, from noninvasive to invasive, from light to sound based, and from morphological to functional parameters.
生物可吸收血管支架（BRS）代表了一种新的方法，旨在提供短暂的血管支持和药物输送能力，而没有金属药物洗脱支架（DES）的长期局限性。该技术有可能克服与金属 DES 相关的许多安全问题，甚至可能带来进一步的临床获益。特别是，BRS 旨在提供短期管腔支持，在完全生物吸收后，消除金属 DES 典型的永久性笼状结构。然而，由于设计、降解速率、机械性能丧失和药物输送能力可能影响其安全性和有效性，因此该技术需要新的成像方式和方法来进行评估。我们提供了一种全面的方法来评估所有现有的生物可吸收装置，包括从非侵入性到侵入性、从基于光到基于声音、从形态学到功能参数的方法。
