Marder Eve, Goeritz Marie L, Otopalik Adriane G
Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States.
Volen Center and Biology Department, Brandeis University, Waltham, MA 02454, United States.
Curr Opin Neurobiol. 2015 Apr;31:156-63. doi: 10.1016/j.conb.2014.10.012. Epub 2014 Nov 6.
Small central pattern generating circuits found in invertebrates have significant advantages for the study of the circuit mechanisms that generate brain rhythms. Experimental and computational studies of small oscillatory circuits reveal that similar rhythms can arise from disparate mechanisms. Animal-to-animal variation in the properties of single neurons and synapses may underly robust circuit performance, and can be revealed by perturbations. Neuromodulation can produce altered circuit performance but also ensure reliable circuit function.
在无脊椎动物中发现的小型中央模式生成电路,对于研究产生脑节律的电路机制具有显著优势。对小型振荡电路的实验和计算研究表明,不同的机制可能产生相似的节律。单个神经元和突触特性在动物个体间的差异可能是强大电路性能的基础,并且可以通过扰动来揭示。神经调节可以改变电路性能,但也能确保电路功能的可靠性。