Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
Curr Opin Microbiol. 2015 Feb;23:86-93. doi: 10.1016/j.mib.2014.11.008. Epub 2014 Nov 27.
The intracellular pathogen Legionella pneumophila (Lp) survives and replicates inside a specialized vacuolar compartment that evades canonical phagosomal maturation. Through the action of a large number of effectors translocated into the host cytosol via the Dot/Icm type IV secretion system, Lp subverts host cell pathways to convert its nascent phagosome into an ER-derived compartment, the Legionella containing vacuole (LCV), which serves as bacterial replication niche.
细胞内病原体嗜肺军团菌 (Lp) 能够在一种特殊的空泡腔内生存和复制，该空泡腔逃避了经典的吞噬体成熟过程。通过 Dot/Icm 型 IV 型分泌系统将大量效应蛋白转运到宿主细胞质中，Lp 颠覆宿主细胞途径，将其新生的吞噬体转化为内质网衍生的隔室，即含有军团菌的空泡 (LCV)，作为细菌复制的栖息地。
