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关于酵母小菌落突变体线粒体基因组结构的争议：通过序列分析解决

A controversy concerning the structure of the mitochondrial genome of a yeast petite mutant: resolution by sequence analysis.

作者信息

Bergantino E, Carignani G

机构信息

Dipartimento di Chimica Biologica dell'Università di Padova, Italy.

出版信息

Curr Genet. 1989 Apr;15(4):291-3; discussion 293-4. doi: 10.1007/BF00447045.

DOI:10.1007/BF00447045
PMID:2546686
Abstract

Sequence analysis was used to define the repeat unit that constitutes the mitochondrial genome of a petite (rho-) mutant of the yeast Saccharomyces cerevisiae. This mutant has retained and amplified in tandem a 2,547 bp segment encompassing the second exon of the oxi3 gene excised from wild-type mtDNA between two direct repeats of 11 nucleotides. The identity of the mtDNA segment retained in this petite has recently been questioned (van der Veen et al., 1988). The results presented here confirm the identity of this mtDNA segment to be that determined previously by restriction mapping (Carignani et al., 1983).

摘要

序列分析用于确定构成酿酒酵母小菌落（rho-）突变体线粒体基因组的重复单元。该突变体串联保留并扩增了一个2547 bp的片段，该片段包含从野生型线粒体DNA中切除的oxi3基因的第二个外显子，位于两个11个核苷酸的正向重复序列之间。最近有人对该小菌落中保留的线粒体DNA片段的一致性提出了质疑（van der Veen等人，1988年）。此处给出的结果证实了该线粒体DNA片段的一致性与先前通过限制性图谱分析确定的一致（Carignani等人，1983年）。

相似文献

1
A controversy concerning the structure of the mitochondrial genome of a yeast petite mutant: resolution by sequence analysis.关于酵母小菌落突变体线粒体基因组结构的争议：通过序列分析解决
Curr Genet. 1989 Apr;15(4):291-3; discussion 293-4. doi: 10.1007/BF00447045.
2
The oli1 gene and flanking sequences in mitochondrial DNA of Saccharomyces cerevisiae: the complete nucleotide sequence of a 1.35 kilobase petite mitochondrial DNA genome covering the oli1 gene.酿酒酵母线粒体DNA中的oli1基因及其侧翼序列：一个覆盖oli1基因的1.35千碱基小线粒体DNA基因组的完整核苷酸序列。
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A GC cluster repeat is a hotspot for mit- macro-deletions in yeast mitochondrial DNA.GC 簇重复序列是酵母线粒体 DNA 中发生有丝分裂大缺失的热点区域。
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Excision sequences in the mitochondrial genome of yeast.酵母线粒体基因组中的切除序列。
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Amphimeric mitochondrial genomes of petite mutants of yeast. I. Flip-flop amphimers make up the mitochondrial genomes of "palindromic" petite mutants of yeast.酵母小菌落突变体的两性线粒体基因组。I. 翻转两性体构成酵母“回文”小菌落突变体的线粒体基因组。
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Fine structure of the 21S ribosomal RNA region on yeast mitochondrial DNA. II. The organization of sequences in petite mitochondrial DNAs carrying genetic markers from the 21S region.酵母线粒体DNA上21S核糖体RNA区域的精细结构。II. 携带来自21S区域遗传标记的小线粒体DNA中序列的组织方式。
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The mitochondrial genomes of spontaneous orir petite mutants of yeast have rearranged repeat units organized as inverted tandem dimers.酵母自发ori小菌落突变体的线粒体基因组具有重排的重复单元，这些重复单元组织成反向串联二聚体。
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Lack of site-specific recombination between mitochondrial genomes of petite mutants of yeast.酵母小菌落突变体线粒体基因组间缺乏位点特异性重组。
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Inversions in mitochondrial DNA of a petite mutant of yeast.
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Petite deletion map of the mitochondrial oxi3 region in Saccharomyces cerevisiae.酿酒酵母线粒体oxi3区域的微小缺失图谱。
Mol Gen Genet. 1979 Jan 2;167(3):301-8. doi: 10.1007/BF00267423.

本文引用的文献

1
Expression of the split gene cob in yeast: evidence for a precursor of a "maturase" protein translated from intron 4 and preceding exons.裂合基因cob在酵母中的表达：从内含子4及之前的外显子翻译出的“成熟酶”蛋白前体的证据。
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Excision sequences in the mitochondrial genome of yeast.酵母线粒体基因组中的切除序列。
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Leakiness of termination codons in mitochondrial mutants of the yeast Saccharomyces cerevisiae.酿酒酵母线粒体突变体中终止密码子的通读现象。
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An mRNA maturase is encoded by the first intron of the mitochondrial gene for the subunit I of cytochrome oxidase in S. cerevisiae.一种mRNA成熟酶由酿酒酵母细胞色素氧化酶亚基I的线粒体基因的第一个内含子编码。
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5
Assembly of the mitochondrial membrane system. Structure and nucleotide sequence of the gene coding for subunit 1 of yeast cytochrme oxidase.线粒体膜系统的组装。酵母细胞色素氧化酶亚基1编码基因的结构与核苷酸序列。
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Assembly of the mitochondrial membrane system. Physical map of the Oxi3 locus of yeast mitochondrial DNA.线粒体膜系统的组装。酵母线粒体DNA的Oxi3基因座物理图谱。
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Leaky +1 and -1 frameshift mutations at the same site in a yeast mitochondrial gene.酵母线粒体基因中同一位置的渗漏性 +1 和 -1 移码突变。
Nature. 1980 Nov 6;288(5786):60-3. doi: 10.1038/288060a0.
8
Excision sites in the GC clusters of the mitochondrial genome of yeast.酵母线粒体基因组GC簇中的切除位点。
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9
RNA splicing in yeast mitochondria: DNA sequence analysis of mit- mutants deficient in the excision of introns aI1 and aI2 of the gene for subunit I of cytochrome c oxidase.酵母线粒体中的RNA剪接：细胞色素c氧化酶亚基I基因的内含子aI1和aI2切除缺陷的mit-突变体的DNA序列分析
Curr Genet. 1988 Mar;13(3):219-26. doi: 10.1007/BF00387767.
10
DNA sequencing with chain-terminating inhibitors.使用链终止抑制剂的DNA测序。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7. doi: 10.1073/pnas.74.12.5463.