长链非编码RNA与肝细胞癌
Long non-coding RNAs and hepatocellular carcinoma.
作者信息
Yu Fu-Jun, Zheng Jian-Jian, Dong Pei-Hong, Fan Xiao-Ming
机构信息
Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508.
Wenzhou Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
出版信息
Mol Clin Oncol. 2015 Jan;3(1):13-17. doi: 10.3892/mco.2014.429. Epub 2014 Sep 25.
Abstract
Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post-transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets.
摘要
转录组分析中新一代测序技术的最新进展有助于识别众多非编码RNA。长链非编码RNA（lncRNA）通常被定义为长度为200 bp至100 kbp且缺乏蛋白质编码潜力的RNA分子。lncRNA在基因表达调控中发挥关键作用，包括染色质修饰、转录和转录后加工。已经证实，lncRNA的失调与多种人类疾病相关，尤其是肿瘤。在本研究中，我们聚焦于肝细胞癌（HCC）中研究最为广泛的lncRNA。大多数lncRNA的生物学功能和分子机制尚未得到研究。对HCC中lncRNA的进一步了解可能有助于识别可作为新型预后标志物和治疗靶点的lncRNA。
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