Huang Biao, Zhang Rongxin
Research Center of Basic Medical Science; Department of Immunology, Basic Medical College; Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironments and Diseases of Educational Ministry of China, Tianjin Medical University, Tianjin, 300070, China.
Mol Biol Rep. 2014 Jun;41(6):3915-23. doi: 10.1007/s11033-014-3259-6. Epub 2014 Feb 19.
The majority of the genomic DNA sequence in mammalian and other higher organisms can be transcribed into abundant functional RNA transcripts, especially regulatory non-coding RNAs (ncRNAs) that are expressed in a developmentally and species-specific regulated manner. Here, we review various regulatory non-coding RNAs, including regulatory small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs), and summarize two and eight kinds of distinct modes of action for sncRNAs and lncRNAs respectively, by which functional ncRNAs mediate the regulation of intracellular events.
哺乳动物和其他高等生物中的大多数基因组DNA序列都可以转录为丰富的功能性RNA转录本，特别是以发育和物种特异性调控方式表达的调控性非编码RNA（ncRNA）。在这里，我们综述了各种调控性非编码RNA，包括调控性小非编码RNA（sncRNA）和长非编码RNA（lncRNA），并分别总结了sncRNA和lncRNA的两种和八种不同作用模式，功能性ncRNA通过这些模式介导细胞内事件的调控。
