Pan Xiao-Feng, Huan Jin-Liang, Qin Xian-Ju
Department of General Surgery, Shanghai Eighth People's Hospital, Shanghai 200235, P.R. China.
Mol Clin Oncol. 2015 Jan;3(1):222-226. doi: 10.3892/mco.2014.430. Epub 2014 Sep 25.
Seroma is a common complication following breast cancer surgery and the controllable predictive factors remain unknown. Patients who underwent mastectomy with axillary dissection between 2008 and 2011 in our hospital were retrospectively investigated. The demographics, clinical characteristics and therapeutic factors of each patient were recorded. The association of seroma incidence with each variable was evaluated by univariate logistic regression analysis. All the variables were considered independent predictors of seroma incidence. The probability of developing seroma following surgery was evaluated by multivariate logistic regression analysis. A total of 102 patients, with a mean age of 54.86±13.02 years (range, 30-89 years), were included in this study and the incidence of seroma was found to be 22.55%. The operative time (P=0.0066, coefficient = 0.0261, OR=1.03) and the use of patient-controlled intravenous analgesia (PCA) (P=0.0002, coefficient = -1.8089, OR=0.03, ref = no) was significantly associated with the incidence of seroma postoperatively. In conclusion, the prediction of the development of seroma following mastectomy with axillary dissection is challenging. However, a longer operative time and the non-use of PCA may represent potential risk factors for this complication.
血清肿是乳腺癌手术后常见的并发症，但其可控的预测因素尚不清楚。对2008年至2011年期间在我院接受乳房切除术并腋窝清扫术的患者进行回顾性研究。记录每位患者的人口统计学、临床特征和治疗因素。通过单因素逻辑回归分析评估血清肿发生率与各变量的相关性。所有变量均被视为血清肿发生率的独立预测因素。通过多因素逻辑回归分析评估手术后发生血清肿的概率。本研究共纳入102例患者，平均年龄54.86±13.02岁（范围30-89岁），血清肿发生率为22.55%。手术时间（P=0.0066，系数=0.0261，OR=1.03）和使用患者自控静脉镇痛（PCA）（P=0.0002，系数=-1.8089，OR=0.03，参照=否）与术后血清肿发生率显著相关。总之，预测乳房切除术并腋窝清扫术后血清肿的发生具有挑战性。然而，手术时间较长和未使用PCA可能是该并发症的潜在危险因素。
