Nwashindi A, Dim E M
Niger J Med. 2014 Oct-Dec;23(4):335-43.
Transosseous wires used in the management of fractures are stainless steel alloys which contain nickel 14.5%, chromium 17.6%, iron 62.5% and molybdenum 2.8%. Gradual disintegration of the transosseous wires release nickel into the blood leading to increase nickel concentration in the blood. Nickel has been found to have some adverse systemic effects on the body. The aim of this paper is to discuss the sources of Nickel in the body as well as the systemic adverse effects of Nickel as a degradation product of stainless steel surgical implants.
A study of pertinent literature on nickel as a content of stainless steel alloy used in implant surgery was done, taking note also of other sources of nickel in the body, the toxicokinetics of nickel and the related adverse effects of this metal and its compound in humans.
As outcome,the sources of human exposure to nickel,distribution and metabolism of nickel in the body, host responseto stainless steel wires and the adverse effects of nickel in the body are presented.
It may be necessary to discourage the use of wires or implants containing nickel in the management of fractures.The need for removal of these implants after they have served their purposes is emphasized.
用于骨折治疗的穿骨钢丝是不锈钢合金，其含有14.5%的镍、17.6%的铬、62.5%的铁和2.8%的钼。穿骨钢丝的逐渐分解会将镍释放到血液中，导致血液中镍浓度升高。已发现镍对身体有一些不良的全身影响。本文的目的是讨论体内镍的来源以及作为不锈钢手术植入物降解产物的镍的全身不良影响。
对有关镍作为植入手术中使用的不锈钢合金成分的相关文献进行了研究，同时也注意到体内镍的其他来源、镍的毒代动力学以及这种金属及其化合物对人体的相关不良影响。
作为研究结果，介绍了人体接触镍的来源、镍在体内的分布和代谢、宿主对不锈钢丝的反应以及镍在体内的不良影响。
在骨折治疗中可能有必要不鼓励使用含镍的钢丝或植入物。强调了在这些植入物完成其使命后将其取出的必要性。
