Hierholzer S, Hierholzer G, Sauer K H, Paterson R S
Arch Orthop Trauma Surg (1978). 1984;102(3):198-200. doi: 10.1007/BF00575233.
Correlation has previously been observed between the incidence of metal hypersensitivity (Ni, Cr, Co) and the incidence of infection after internal fixation of bone fractures. As there is no doubt that exposure to high concentrations of metal can cause allergy, metal levels (Cr, Ni, Mo, Co) were analyzed in implant contact tissues by ASS. Both the absolute concentration of the ions and the Ni:Cr ratio in the tissues adjacent to metal implants is greater in infected cases than in non-infected. Thus infection as a cause of allergy has to be considered. In view of the resulting problems perhaps consideration could be given to the use of a different alloy for metal implants.
先前已观察到金属过敏（镍、铬、钴）的发生率与骨折内固定术后感染的发生率之间存在相关性。由于毫无疑问，接触高浓度金属会引起过敏，因此通过原子吸收光谱法（ASS）分析了植入物接触组织中的金属含量（铬、镍、钼、钴）。感染病例中，金属植入物相邻组织中离子的绝对浓度和镍与铬的比例均高于未感染病例。因此，必须考虑感染作为过敏原因的可能性。鉴于由此产生的问题，或许可以考虑使用不同的合金来制造金属植入物。
