Yan L, Xi Z, Drettner B
Department of Otorhinolaryngology, Guangdong Provincial People's Hospital, People's Republic of China.
Acta Otolaryngol. 1989 May-Jun;107(5-6):424-7. doi: 10.3109/00016488909127534.
In the city of Guangzhou (Canton) and its surroundings nasopharyngeal cancer (NPC) constitutes about 32% of all cancer and is therefore the most common kind of cancer. Three types of etiological factors seem to be involved: 1) a hereditary factor, 2) Epstein-Barr virus, and 3) external factors in food and water. An epidemiological study has been started in the Guangzhou area with interviews of NPC cases, matching controls and mothers of the cases and controls concerning especially food and environmental factors and infections in childhood. The questions put to the controls and cases covered the last seven years and the age of ten, while those to the mothers covered the first three years of life and the age of ten for the controls and cases. Results are now available for 140 cases, 140 controls and the corresponding living mothers. They indicate that salted fish, particularly of Cantonese style, was consumed more by NPC cases than by controls and also had more frequently been given to weaning children in whom NPC later developed. Furthermore, salted vegetables and salted pork were consumed to a greater extent by NPC cases than by controls. Drinking of polluted water in childhood was more common among the NPC cases. Consumption of fresh fruit was more rare among the cases. Most of the NPC cases had a positive VCA-IgA titre.
在广州市及其周边地区，鼻咽癌（NPC）约占所有癌症病例的32%，因此是最常见的癌症类型。病因似乎涉及三种因素：1）遗传因素，2）爱泼斯坦-巴尔病毒，以及3）食物和水中的外部因素。在广州地区已启动一项流行病学研究，对鼻咽癌病例、匹配的对照以及病例和对照的母亲进行访谈，特别关注食物和环境因素以及儿童时期的感染情况。向对照和病例提出的问题涵盖过去七年及十岁时的情况，而向母亲提出的问题涵盖生命的头三年以及对照和病例十岁时的情况。目前已获得140例病例、140名对照以及相应在世母亲的结果。结果表明，鼻咽癌病例比对照更多地食用咸鱼，尤其是广东风味的咸鱼，而且后来患鼻咽癌的断奶儿童食用咸鱼的频率也更高。此外，鼻咽癌病例比对照更多地食用腌菜和咸猪肉。鼻咽癌病例童年时期饮用受污染水的情况更为常见。病例食用新鲜水果的情况更为少见。大多数鼻咽癌病例的VCA-IgA滴度呈阳性。
