乳腺癌检测示范项目随访队列中的睡眠时长与乳腺癌风险
Sleep duration and breast cancer risk in the Breast Cancer Detection Demonstration Project follow-up cohort.
作者信息
Qian X, Brinton L A, Schairer C, Matthews C E
机构信息
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
出版信息
Br J Cancer. 2015 Feb 3;112(3):567-71. doi: 10.1038/bjc.2014.600. Epub 2014 Dec 4.
BACKGROUND
Short sleep has been hypothesised to increase the risk of breast cancer. However, little is known about the association between sleep and different subtypes of breast cancer defined by hormone receptor status.
METHODS
Among 40 013 women in the Breast Cancer Detection Demonstration Project, including 1846 incident breast cancer cases, we prospectively examined self-reported weekday and weekend sleep duration in relation to breast cancer risk. We used multivariate Cox proportional hazards regression models to estimate relative risks (RRs) and 95% confidence intervals (CIs).
RESULTS
We found no association between sleep and overall breast cancer. However, we observed a decreased risk of ER+PR+ breast cancer (RR <6 vs 8 - 9 h (95% CI): 0.54 (0.31, 0.93), P for trend, 0.003) with shorter sleep duration.
CONCLUSIONS
Our finding does not support an association between sleep duration and overall breast cancer risk. However, the effect of sleep on different subtypes of breast cancer deserves further investigation.
背景
有假说认为睡眠不足会增加患乳腺癌的风险。然而，关于睡眠与根据激素受体状态定义的不同亚型乳腺癌之间的关联，人们了解甚少。
方法
在乳腺癌检测示范项目的40013名女性中，包括1846例新发乳腺癌病例，我们前瞻性地研究了自我报告的工作日和周末睡眠时间与乳腺癌风险的关系。我们使用多变量Cox比例风险回归模型来估计相对风险（RRs）和95%置信区间（CIs）。
结果
我们发现睡眠与总体乳腺癌之间没有关联。然而，我们观察到睡眠时间较短时，ER+PR+乳腺癌的风险降低（RR<6小时与8 - 9小时相比（95%CI）：0.54（0.31，0.93），趋势P值为0.003）。
结论
我们的研究结果不支持睡眠时间与总体乳腺癌风险之间存在关联。然而，睡眠对不同亚型乳腺癌的影响值得进一步研究。
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