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山莨菪碱和新斯的明联合治疗对梗阻性黄疸大鼠肝切除术后炎症反应和肝再生的影响。

Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy.

机构信息

Department & Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing 100853, China.

出版信息

Biomed Res Int. 2014;2014:362024. doi: 10.1155/2014/362024. Epub 2014 Nov 12.

DOI:10.1155/2014/362024
PMID:25478569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4244971/
Abstract

BACKGROUND

Cholestasis is associated with high rates of morbidity and mortality in patients undergoing major liver resection. This study aimed to evaluate the effects of a combined anisodamine and neostigmine (Ani+Neo) treatment on the inflammatory response and liver regeneration in rats with obstructive jaundice (OJ) after partial hepatectomy.

MATERIALS AND METHODS

OJ was induced in the rats by bile duct ligation. After 7 days biliary drainage and partial hepatectomy were performed. These rats were assigned to a saline group or an Ani+Neo treatment group. The expressions of inflammatory mediators, liver regeneration, and liver damage were assessed at 48 h after hepatectomy.

RESULTS

The mRNA levels of TNF-α, IL-1β, IL-6, MCP-1, and MIP-1α, in the remnant livers, and the serum levels of TNF-α and IL-1β were substantially reduced in the Ani+Neo group compared with saline group (P<0.05). The Ani+Neo treatment obviously promoted liver regeneration as indicated by the liver weights and Ki-67 labeling index (P<0.05). The serum albumin and γ-GT levels and liver neutrophil infiltration also significantly improved in the Ani+Neo group (P<0.05) compared with the saline group.

CONCLUSIONS

These results demonstrate that the combined anisodamine and neostigmine treatment is able to improve the liver regeneration in rats with OJ by substantially alleviating the inflammatory response.

摘要

背景

在接受大肝切除术的患者中，胆汁淤积与高发病率和死亡率相关。本研究旨在评估山莨菪碱和新斯的明（Ani+Neo）联合治疗对梗阻性黄疸（OJ）大鼠部分肝切除后炎症反应和肝再生的影响。

材料和方法

通过胆管结扎诱导大鼠 OJ。7 天后进行胆汁引流和部分肝切除术。这些大鼠被分为盐水组或 Ani+Neo 治疗组。肝切除后 48 小时评估炎症介质、肝再生和肝损伤的表达。

结果

与盐水组相比，Ani+Neo 组残肝中 TNF-α、IL-1β、IL-6、MCP-1 和 MIP-1α 的 mRNA 水平以及血清 TNF-α 和 IL-1β 水平均显著降低（P<0.05）。Ani+Neo 治疗明显促进了肝再生，表现为肝重和 Ki-67 标记指数增加（P<0.05）。与盐水组相比，Ani+Neo 组血清白蛋白和γ-GT 水平以及肝中性粒细胞浸润也明显改善（P<0.05）。

结论

这些结果表明，山莨菪碱和新斯的明联合治疗能够通过显著减轻炎症反应来改善 OJ 大鼠的肝再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/3df50e69f6cf/BMRI2014-362024.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/be526a3670a0/BMRI2014-362024.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/db4b70432c77/BMRI2014-362024.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/3786f75be3cf/BMRI2014-362024.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/d4e2e551c49d/BMRI2014-362024.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/3df50e69f6cf/BMRI2014-362024.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/be526a3670a0/BMRI2014-362024.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/db4b70432c77/BMRI2014-362024.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/3786f75be3cf/BMRI2014-362024.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/d4e2e551c49d/BMRI2014-362024.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba14/4244971/3df50e69f6cf/BMRI2014-362024.005.jpg

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