Indulekha Karunakaran, Surendar Jayagopi, Anjana Ranjit Mohan, Geetha Loganathan, Gokulakrishnan Kuppan, Pradeepa Rajendra, Mohan Viswanathan
Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, International Diabetes Federation Centre of Education , Gopalapuram, Chennai, India .
Diabetes Technol Ther. 2015 Feb;17(2):134-41. doi: 10.1089/dia.2014.0202. Epub 2014 Dec 5.
This study looked at the association of adipokines, inflammatory and oxidative stress markers in subjects with the following phenotypes: metabolically healthy, nonobese (MHNO), metabolically healthy, obese (MHO), metabolically obese, nonobese (MONO), and metabolically obese, obese (MOO).
Subjects with MHNO (n=462), MHO (n=192), MONO (n=315), and MOO (n=335) were randomly selected from the Chennai Urban Rural Epidemiology Study. Adiponectin, visfatin, resistin, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), oxidized low-density lipoprotein (LDL), and monocyte chemoattractant protein-1 (MCP-1) were measured by enzyme-linked immunosorbent assay.
Levels of adiponectin were lowest in the MOO group, followed by the MONO, MHO, and the MHNO groups (P=0.042), whereas the levels of visfatin (P=0.042) and resistin (P=0.043) were highest in the MOO group, followed by the MONO, MHO, and the MHNO groups. Levels of hs-CRP (P=0.029), TNF-α (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes. Linear regression analysis of the parameters with body mass index (BMI) and metabolic syndrome components showed that adiponectin is negatively associated with abdominal obesity (β=-0.060; P=0.039) and BMI (β=-0.076; P=0.009) and that TNF-α is negatively associated with high-density lipoprotein levels (β=0.114, P=0.049) even after adjusting for age and gender. hs-CRP (β=0.112, P=0.020) and oxidized LDL (β=0.114, P=0.050) showed a positive association with systolic blood pressure even after adjusting for age and gender.
The metabolically obese phenotype is characterized by altered adipokine and inflammatory profiles, which could make this phenotype at high risk for type 2 diabetes mellitus and cardiovascular diseases.
本研究探讨了具有以下表型的受试者中脂联素、炎症和氧化应激标志物之间的关联：代谢健康、非肥胖（MHNO），代谢健康、肥胖（MHO），代谢性肥胖、非肥胖（MONO），以及代谢性肥胖、肥胖（MOO）。
从金奈城乡流行病学研究中随机选取MHNO（n = 462）、MHO（n = 192）、MONO（n = 315）和MOO（n = 335）的受试者。采用酶联免疫吸附测定法测量脂联素、内脂素、抵抗素、高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、氧化型低密度脂蛋白（LDL）和单核细胞趋化蛋白-1（MCP-1）。
脂联素水平在MOO组中最低，其次是MONO组、MHO组和MHNO组（P = 0.042），而内脂素（P = 0.042）和抵抗素（P = 0.043）水平在MOO组中最高，其次是MONO组、MHO组和MHNO组。hs-CRP（P = 0.029）TNF-α（P = 0.036）、IL-6（P = 0.042）、氧化型LDL（P = 0.036）和MCP-1（P = 0.039）水平从MHNO表型到MHO表型、再到MONO表型、最后到MOO表型逐渐升高。对这些参数与体重指数（BMI）和代谢综合征组分进行线性回归分析显示，即使在调整年龄和性别后，脂联素与腹型肥胖（β = -0.060；P = 0.039）和BMI（β = -0.076；P = 0.009）呈负相关，TNF-α与高密度脂蛋白水平呈负相关（β = 0.114，P = 0.049）。即使在调整年龄和性别后，hs-CRP（β = 0.112，P = 0.020）和氧化型LDL（β = 0.114，P = 0.050）与收缩压呈正相关。
代谢性肥胖表型的特征是脂联素和炎症谱改变，这可能使该表型处于患2型糖尿病和心血管疾病的高风险中。
