Garcia Zozaya J L, Padilla Viloria M, Castro A
Nephrology Service, Hospital Central, Universidad de Carabobo, Valencia, Venezuela.
South Med J. 1987 Oct;80(10):1224-7.
We studied 52 patients with mild to severe essential arterial hypertension and ranging in age from 30 to 60 years (average, 44). Various biochemical and endocrinologic parameters were studied, with special emphasis on plasma aldosterone and urinary aldosterone. At the same time, a control group of 30 normal subjects (nonhypertensive) were studied under the same conditions. Both groups were carefully selected. Results indicated that the hypertensive group demonstrated a marked increase in plasma aldosterone levels (P less than .01) and an increase in the coefficient of plasma aldosterone/plasma renin activity (P less than .01). This indicates inadequate secretion of plasma aldosterone. There were no significant changes in the urinary aldosterone. Statistically significant changes were found in plasma renin activity (P less than .001) and plasma aldosterone (P less than .001) when the hypertensive patients were divided into two age groups, those under 45 and those over 45. These changes were not found in the normal subjects in the same age groups, indicating that age is an important influence on the renin-aldosterone system in hypertensive patients, and leads to variations in this hormonal axis similar to those observed in normal elderly subjects.
我们研究了52例年龄在30至60岁（平均44岁）之间、患有轻度至重度原发性动脉高血压的患者。研究了各种生化和内分泌参数，特别着重于血浆醛固酮和尿醛固酮。同时，在相同条件下对30名正常受试者（非高血压患者）组成的对照组进行了研究。两组均经过精心挑选。结果表明，高血压组血浆醛固酮水平显著升高（P<0.01），血浆醛固酮/血浆肾素活性系数升高（P<0.01）。这表明血浆醛固酮分泌不足。尿醛固酮无显著变化。将高血压患者分为45岁以下和45岁以上两个年龄组时，血浆肾素活性（P<0.001）和血浆醛固酮（P<0.001）有统计学意义的变化。在相同年龄组的正常受试者中未发现这些变化，这表明年龄对高血压患者的肾素-醛固酮系统有重要影响，并导致该激素轴出现类似于正常老年受试者中观察到的变化。
