• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Fasting levels of hepatic p-S6 are increased in old mice.老年小鼠肝脏中磷酸化核糖体蛋白S6的空腹水平升高。
Cell Cycle. 2014;13(17):2656-9. doi: 10.4161/15384101.2014.949150.
2
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.雷帕霉素作用机制或哺乳动物雷帕霉素靶蛋白（mTOR）可能以加速衰老为代价来决定年轻雄性小鼠的强健程度。
Aging (Albany NY). 2012 Dec;4(12):899-916. doi: 10.18632/aging.100528.
3
Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.亚急性热量限制和雷帕霉素对小鼠肝脏蛋白质组稳态的影响不一致，并能逆转衰老效应。
Aging Cell. 2015 Aug;14(4):547-57. doi: 10.1111/acel.12317. Epub 2015 Mar 23.
4
Dysregulation of the mTOR pathway in p53-deficient mice.p53基因缺陷小鼠中mTOR信号通路的失调
Cancer Biol Ther. 2013 Dec;14(12):1182-8. doi: 10.4161/cbt.26947. Epub 2013 Nov 1.
5
Involvement of PI3K-AKT-mTOR pathway in protein kinase CKII inhibition-mediated senescence in human colon cancer cells.PI3K-AKT-mTOR 通路在蛋白激酶 CKII 抑制介导的人结肠癌细胞衰老中的作用。
Biochem Biophys Res Commun. 2013 Apr 19;433(4):420-5. doi: 10.1016/j.bbrc.2013.02.108. Epub 2013 Mar 21.
6
Impact of fasting on the rhythmic expression of myogenic and metabolic factors in skeletal muscle of adult mice.禁食对成年小鼠骨骼肌中成肌和代谢因子节律表达的影响。
Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C26-35. doi: 10.1152/ajpcell.00027.2013. Epub 2013 Apr 17.
7
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.蛋氨酸限制通过内源性硫化氢延缓肾脏衰老并抑制衰老相关分泌表型。
Cell Cycle. 2019 Jul;18(14):1573-1587. doi: 10.1080/15384101.2019.1618124. Epub 2019 Jun 5.
8
Medium-chain triacylglycerol suppresses the decrease of plasma albumin level through the insulin-Akt-mTOR pathway in the livers of malnourished rats.中链甘油三酯通过胰岛素-Akt-mTOR途径抑制营养不良大鼠肝脏中血浆白蛋白水平的降低。
J Nutr Sci Vitaminol (Tokyo). 2013;59(2):123-8. doi: 10.3177/jnsv.59.123.
9
Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways.雄性小鼠短期热量限制会使基因表达女性化，并改变保守衰老调节途径的关键调节因子。
PLoS One. 2009;4(4):e5242. doi: 10.1371/journal.pone.0005242. Epub 2009 Apr 16.
10
AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.AMPD1通过调控mTORC1-p70 S6激酶轴来控制骨骼肌中的胰岛素敏感性。
BMC Endocr Disord. 2015 Mar 27;15:11. doi: 10.1186/s12902-015-0010-9.

引用本文的文献

1
Targeting the biology of aging with mTOR inhibitors.用 mTOR 抑制剂靶向衰老的生物学。
Nat Aging. 2023 Jun;3(6):642-660. doi: 10.1038/s43587-023-00416-y. Epub 2023 May 4.
2
Hallmarks of Aging in the Liver.肝脏衰老的特征
Comput Struct Biotechnol J. 2019 Aug 7;17:1151-1161. doi: 10.1016/j.csbj.2019.07.021. eCollection 2019.
3
Fasting and rapamycin: diabetes versus benevolent glucose intolerance.禁食和雷帕霉素：糖尿病与良性葡萄糖耐量受损。
Cell Death Dis. 2019 Aug 13;10(8):607. doi: 10.1038/s41419-019-1822-8.
4
mTOR as a central regulator of lifespan and aging.mTOR作为寿命和衰老的核心调节因子。
F1000Res. 2019 Jul 2;8. doi: 10.12688/f1000research.17196.1. eCollection 2019.
5
Disease or not, aging is easily treatable.无论是否患病，衰老都易于治疗。
Aging (Albany NY). 2018 Nov 17;10(11):3067-3078. doi: 10.18632/aging.101647.
6
Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy.有证据表明线粒体死亡螺旋是拮抗多效性的基础。
Aging Cell. 2017 Jun;16(3):435-443. doi: 10.1111/acel.12579. Epub 2017 Feb 9.
7
Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice.mTOR信号通路过度活跃会导致老年女性和小鼠出现子宫内膜增生。
Oncotarget. 2017 Jan 31;8(5):7265-7275. doi: 10.18632/oncotarget.13919.
8
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.雷帕霉素的作用机制靶点：新陈代谢与衰老的主要传导者
Cell Metab. 2016 Jun 14;23(6):990-1003. doi: 10.1016/j.cmet.2016.05.009.
9
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.寻找庞塞·德莱昂之药：抗衰老分子筛选中的挑战。
F1000Res. 2016 Mar 29;5. doi: 10.12688/f1000research.7821.1. eCollection 2016.
10
Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.与年龄相关的mTOR活性增加促成卵巢表面上皮的病理变化。
Oncotarget. 2016 Apr 12;7(15):19214-27. doi: 10.18632/oncotarget.8468.

本文引用的文献

1
Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.接触抑制和高细胞密度会使哺乳动物雷帕霉素靶蛋白通路失活，从而抑制衰老程序。
Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8832-7. doi: 10.1073/pnas.1405723111. Epub 2014 Jun 2.
2
Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration.雷帕霉素信号通路靶点通过必需氨基酸改变介导饮食限制的寿命延长效应。
Aging (Albany NY). 2014 May;6(5):390-8. doi: 10.18632/aging.100665.
3
Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium.雷帕霉素可逆转高糖培养基中的胰岛素抵抗（IR），而在正常血糖培养基中不会引起胰岛素抵抗。
Cell Death Dis. 2014 May 8;5(5):e1214. doi: 10.1038/cddis.2014.178.
4
Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.每周给予雷帕霉素可提高高脂饮食肥胖雄性小鼠的存活率并改善生物标志物。
Aging Cell. 2014 Aug;13(4):616-22. doi: 10.1111/acel.12211. Epub 2014 Mar 22.
5
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.低蛋白摄入量与65岁及以下人群而非老年人群中胰岛素样生长因子-1（IGF-1）的大幅降低、癌症及总体死亡率相关。
Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006.
6
Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin.低剂量间歇性使用雷帕霉素治疗的HER-2/neu转基因小鼠的寿命延长及癌症预防
Cancer Biol Ther. 2014 May;15(5):586-92. doi: 10.4161/cbt.28164. Epub 2014 Feb 20.
7
M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue.衰老中假性缺氧状态的驱动因素：雷帕霉素来拯救
Cell Cycle. 2014;13(4):509-15. doi: 10.4161/cc.27973. Epub 2014 Jan 23.
8
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.喂食雷帕霉素的小鼠寿命延长，其肝脏转录组发生重大变化。
PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014.
9
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.雷帕霉素介导的小鼠寿命延长具有剂量和性别依赖性，且在代谢方面与饮食限制不同。
Aging Cell. 2014 Jun;13(3):468-77. doi: 10.1111/acel.12194. Epub 2014 Feb 9.
10
CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.CDK4/6 抑制剂在衰老中替代 p21 和 p16：细胞周期阻滞的持续时间和 MTOR 活性决定了衰老的转化。
Cell Cycle. 2013 Sep 15;12(18):3063-9. doi: 10.4161/cc.26130. Epub 2013 Aug 22.

老年小鼠肝脏中磷酸化核糖体蛋白S6的空腹水平升高。

Fasting levels of hepatic p-S6 are increased in old mice.

作者信息

Leontieva Olga V, Paszkiewicz Geraldine M, Blagosklonny Mikhail V

机构信息

a Cell Stress Biology; Roswell Park Cancer Institute ; Buffalo , NY USA.

出版信息

Cell Cycle. 2014;13(17):2656-9. doi: 10.4161/15384101.2014.949150.

DOI:10.4161/15384101.2014.949150
PMID:25486351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4612665/
Abstract

TOR is involved in aging in a wide range of species from yeast to mammals. Here we show that, after overnight fasting, mTOR activity is higher in the livers of 28 months old female mice compared with middle-aged mice. Taken together with previous reports, our data predict that the life-extending effect of calorie restriction (CR) may be diminished, if CR is started in very old age. In contrast, rapamycin is known to be effective, even when started late in life.

摘要

TOR参与从酵母到哺乳动物等多种物种的衰老过程。我们在此表明，经过一夜禁食后，28月龄雌性小鼠肝脏中的mTOR活性高于中年小鼠。结合先前的报道，我们的数据预测，如果在非常老龄时开始限制热量摄入（CR），其延长寿命的效果可能会减弱。相比之下，已知雷帕霉素即使在生命后期开始使用也有效。