荨麻提取物对二度烧伤创面的愈合作用。
The healing effect of nettle extract on second degree burn wounds.
作者信息
Akbari Hosein, Fatemi Mohammad Javad, Iranpour Maryam, Khodarahmi Ali, Baghaee Mehrdad, Pedram Mir Sepehr, Saleh Sahar, Araghi Shirin
机构信息
Department of Plastic Surgery, Iran University of Medical Sciences, Tehran, Iran;
Department of Plastic and Reconstructive Surgery, Burn Research Center, Hazrat Fatima Hospital, Iran University of Medical Sciences, Tehran, Iran.
出版信息
World J Plast Surg. 2015 Jan;4(1):23-8.
BACKGROUND
Numerous studies were carried out to develop more sophisticated dressings to expedite healing processes and diminish the bacterial burden in burn wounds. This study assessed the healing effect of nettle extract on second degree burns wound in rats in comparison with silver sulfadiazine and vaseline.
METHODS
Forty rats were randomly assigned to four equal groups. A deep second-degree burn was created on the back of each rat using a standard burning procedure. The burns were dressed daily with nettle extract in group 1, silver sulfadiazine in group 2, vaseline in group 3 and without any medication in group 4 as control group. The response to treatment was assessed by digital photography during the treatment until day 42. Histological scoring was undertaken for scar tissue samples on days 10 and 42.
RESULTS
A statistically significant difference was observed in group 1 compared with other groups regarding 4 scoring parameters after 10 days. A statistically significant difference was seen for fibrosis parameter after 42 days. In terms of difference of wound surface area, maximal healing was noticed at the same time in nettle group and minimal repair in the control group.
CONCLUSION
Our findings showed maximal rate of healing in the nettle group. So it may be a suitable substitute for silver sulfadiazine and vaseline when available.
背景
开展了大量研究以开发更先进的敷料，以加快愈合过程并减少烧伤创面的细菌负荷。本研究评估了荨麻提取物与磺胺嘧啶银和凡士林相比，对大鼠二度烧伤创面的愈合效果。
方法
将40只大鼠随机分为四组，每组数量相等。采用标准烫伤程序在每只大鼠背部造成深二度烧伤。第1组每日用荨麻提取物换药，第2组用磺胺嘧啶银，第3组用凡士林，第4组不使用任何药物作为对照组。在治疗至第42天期间，通过数码摄影评估治疗反应。在第10天和第42天对瘢痕组织样本进行组织学评分。
结果
治疗10天后，第1组在4个评分参数方面与其他组相比存在统计学显著差异。42天后，纤维化参数存在统计学显著差异。就创面面积差异而言，荨麻组愈合最快，对照组修复最少。
结论
我们的研究结果表明荨麻组愈合速度最快。因此，在有条件时，它可能是磺胺嘧啶银和凡士林的合适替代品。
Zotero 插件