Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster, Shore Road, Newtownabbey, Co. Antrim, BT37 0QB Northern Ireland, UK.
Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster, Shore Road, Newtownabbey, Co. Antrim, BT37 0QB Northern Ireland, UK.
Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:290-300. doi: 10.1016/j.msec.2014.10.046. Epub 2014 Oct 23.
The bioactivity of hydroxyapatite (HA) coatings can be modified by the addition of different ions, such as silicon (Si), lithium (Li), magnesium (Mg), zinc (Zn) or strontium (Sr) into the HA lattice. Of the ions listed here, strontium substituted hydroxyapatite (SrHA) coatings have received a lot of interest recently as Sr has been shown to promote osteoblast proliferation and differentiation, and reduce osteoclast activity. In this study, SrHA coatings were deposited onto titanium substrates using radio frequency (RF) magnetron co-sputtering (and compared to those surfaces deposited from HA alone). FTIR, XPS, XRD, and SEM techniques were used to analyse the different coatings produced, whereby different combinations of pure HA and 13% Sr-substituted HA targets were investigated. The results highlight that Sr could be successfully incorporated into the HA lattice to form SrHA coatings. It was observed that as the number of SrHA sputtering targets in the study were increased (increasing Sr content), the deposition rate decreased. It was also shown that as the Sr content of the coatings increased, so did the degree of preferred 002 orientation of the coating (along with obvious changes in the surface morphology). This study has shown that RF magnetron sputtering (specifically co-sputtering), offers an appropriate methodology to control the surface properties of Sr-substituted HA, such as the crystallinity, stoichiometry, phase purity and surface morphology.
羟基磷灰石（HA）涂层的生物活性可以通过向 HA 晶格中添加不同的离子来修饰，例如硅（Si）、锂（Li）、镁（Mg）、锌（Zn）或锶（Sr）。在列出的这些离子中，锶取代的羟基磷灰石（SrHA）涂层最近受到了很多关注，因为研究表明锶可以促进成骨细胞的增殖和分化，并减少破骨细胞的活性。在这项研究中，使用射频（RF）磁控溅射在钛基体上沉积 SrHA 涂层（并与单独沉积的 HA 涂层进行了比较）。使用傅里叶变换红外光谱（FTIR）、X 射线光电子能谱（XPS）、X 射线衍射（XRD）和扫描电子显微镜（SEM）技术分析不同的涂层，其中研究了不同的纯 HA 和 13% Sr 取代的 HA 靶材的组合。结果表明 Sr 可以成功地掺入到 HA 晶格中形成 SrHA 涂层。研究发现，随着研究中 SrHA 溅射靶材数量的增加（Sr 含量增加），沉积速率降低。研究还表明，随着涂层中 Sr 含量的增加，涂层的 002 择优取向程度也随之增加（同时涂层的表面形貌也发生了明显的变化）。本研究表明，射频磁控溅射（特别是共溅射）提供了一种合适的方法来控制 Sr 取代 HA 的表面特性，例如结晶度、化学计量比、相纯度和表面形貌。
