Robinson L, Salma-Ancane K, Stipniece L, Meenan B J, Boyd A R
Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, University of Ulster, Shore Road, Newtownabbey, Co. Antrim, BT37 0QB, Northern Ireland, UK.
Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka 3, Riga, LV, 1007, Latvia.
J Mater Sci Mater Med. 2017 Mar;28(3):51. doi: 10.1007/s10856-017-5846-2. Epub 2017 Feb 14.
The in vitro and in vivo performance of hydroxyapatite (HAp) coatings can be modified by the addition of different trace ions, such as silicon (Si), lithium (Li), magnesium (Mg), zinc (Zn) or strontium (Sr) into the HAp lattice, to more closely mirror the complex chemistry of human bone. To date, most of the work in the literature has considered single ion-substituted materials and coatings, with limited reports on co-substituted calcium phosphate systems. The aim of this study was to investigate the potential of radio frequency magnetron sputtering to deposit Sr and Zn co-substituted HAp coatings using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The FTIR and XPS results highlight that all of the Sr, Zn and Sr-Zn co-substituted surfaces produced are all dehydroxylated and are calcium deficient. All of the coatings contained HPO groups, however; only the pure HAp coating and the Sr substituted HAp coating contained additional CO groups. The XRD results highlight that none of the coatings produced in this study contain any other impurity CaP phases, showing peaks corresponding to that of ICDD file #01-072-1243 for HAp, albeit shifted to lower 2θ values due to the incorporation of Sr into the HAp lattice for Ca (in the Sr and Sr-Zn co-substituted surfaces only). Therefore, the results here clearly show that RF magnetron sputtering offers a simple means to deliver Sr and Zn co-substituted HAp coatings with enhanced surface properties. (a) XRD patterns for RF magnetron sputter deposited hydroxyapatite coatings and (b)-(d) for Sr, Zn and Sr-Zn co-substituted coatings, respectively. The XPS spectra in (b) confirms the presence of a HA sputter deposited coating as opposed to
通过向羟基磷灰石（HAp）晶格中添加不同的痕量离子，如硅（Si）、锂（Li）、镁（Mg）、锌（Zn）或锶（Sr），可以改变HAp涂层的体外和体内性能，使其更接近人体骨骼的复杂化学组成。迄今为止，文献中的大多数研究都集中在单离子取代的材料和涂层上，关于共取代磷酸钙体系的报道有限。本研究的目的是利用傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）和X射线光电子能谱（XPS）研究射频磁控溅射沉积Sr和Zn共取代HAp涂层的潜力。FTIR和XPS结果表明，所制备的所有Sr、Zn和Sr-Zn共取代表面均为脱羟基化且缺钙的。然而，所有涂层都含有HPO基团；只有纯HAp涂层和Sr取代的HAp涂层含有额外的CO基团。XRD结果表明，本研究中制备的涂层均不包含任何其他杂质CaP相，显示出与ICDD文件#01-072-1243中HAp相对应的峰，尽管由于Sr取代了HAp晶格中的Ca（仅在Sr和Sr-Zn共取代表面），峰移至较低的2θ值。因此，这里的结果清楚地表明，射频磁控溅射提供了一种简单的方法来制备具有增强表面性能的Sr和Zn共取代HAp涂层。（a）射频磁控溅射沉积的羟基磷灰石涂层的XRD图谱，（b）-（d）分别为Sr、Zn和Sr-Zn共取代涂层的XRD图谱。（b）中的XPS光谱证实了溅射沉积的HA涂层的存在，与……相对
