吡咯喹啉醌对糖皮质激素处理后发育中鸡胚白内障形成及晶状体和肝脏谷胱甘肽含量下降的预防作用。

Preventive effects of pyrroloquinoline quinone on formation of cataract and decline of lenticular and hepatic glutathione of developing chick embryo after glucocorticoid treatment.

作者信息

Nishigori H, Yasunaga M, Mizumura M, Lee J W, Iwatsuru M

机构信息

Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.

出版信息

Life Sci. 1989;45(7):593-8. doi: 10.1016/0024-3205(89)90044-1.

DOI:10.1016/0024-3205(89)90044-1

PMID:2549318

Abstract

When 0.25 mumol of hydrocortisone succinate sodium (HC) was administered to 15-day-old fertile eggs, almost all lenses of chick embryos treated with HC for 48 hr were classified as cataract stage IV-V (95%). A triple application of potassium pyrroloquinoline quinone (PQQ) (1.25 mumol/egg) at 3, 10 and 20 hr after HC treatment showed a preventive effect against the HC-induced cataract formation (I:45%, II:25%, III: 30%). PQQ also prevented the decline of GSH in the lens caused by HC. The decline of GSH in liver 24 hr after HC administration was prevented by PQQ. These data indicate that PQQ can modify HC-induced effects and that the preventive effect of PQQ against HC-induced decline of hepatic GSH seemed to influence HC-induced events in lens.

摘要

当向15日龄的可孵化鸡蛋施用0.25微摩尔的琥珀酸氢化可的松钠（HC）时，用HC处理48小时的鸡胚的几乎所有晶状体都被分类为IV - V期白内障（95%）。在HC处理后3、10和20小时三次施用吡咯并喹啉醌（PQQ）（1.25微摩尔/蛋）显示出对HC诱导的白内障形成的预防作用（I期：45%，II期：25%，III期：30%）。PQQ还防止了HC引起的晶状体中谷胱甘肽（GSH）的下降。PQQ可防止HC给药24小时后肝脏中GSH的下降。这些数据表明，PQQ可以改变HC诱导的效应，并且PQQ对HC诱导的肝脏GSH下降的预防作用似乎影响了HC诱导的晶状体中的事件。