Nishigori H, Lee J W, Iwatsuru M
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Ophthalmic Res. 1995;27(6):350-5. doi: 10.1159/000267747.
When 0.25 mumol of hydrocortisone succinate sodium (HC) was administered to 15-day-old hen's fertile eggs, almost all lenses of the embryos became cataractous with stages IV-V (> 90%) 48 h after the treatment. However, a triple application of propylene glycol (1.5 mmol/egg) at 3, 10 and 20 h after HC treatment effectively prevented the HC-induced cataract formation (I: 84%, II: 12%, III: 4%, IV-V: 0%) and repressed the decline of glutathione and the elevation of lipid peroxide in the lens caused by HC. Propylene glycol is metabolized to lactate and pyruvate producing NADH and is known to possess protective activities against X-ray irradiation. These properties have modified the HC-induced effects and decreased the production of oxidative stress in ovo, protecting the lens from losing its transparency after HC administration. Furthermore, a marked elevation of glucose in cataractous lenses noted after HC administration was not directly involved in opacification of the lenses.
当向15日龄母鸡的受精卵施用0.25微摩尔琥珀酸钠氢化可的松（HC）时，处理后48小时，几乎所有胚胎的晶状体都出现IV - V期白内障（> 90%）。然而，在HC处理后3、10和20小时三次施用丙二醇（1.5毫摩尔/卵）可有效预防HC诱导的白内障形成（I期：84%，II期：12%，III期：4%，IV - V期：0%），并抑制HC引起的晶状体中谷胱甘肽的下降和脂质过氧化物的升高。丙二醇代谢为乳酸和丙酮酸，产生NADH，已知具有抗X射线辐射的保护活性。这些特性改变了HC诱导的效应，减少了卵内氧化应激的产生，保护晶状体在施用HC后不失去透明度。此外，HC施用后白内障晶状体中葡萄糖的显著升高与晶状体混浊没有直接关系。
