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余甘子果实甲醇提取物在实验动物中的抗伤害感受和抗炎活性。

Antinociceptive and anti-inflammatory activities of Bridelia retusa methanolic fruit extract in experimental animals.

作者信息

Kumar Tekeshwar, Jain Vishal

机构信息

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh 492 010, India.

出版信息

ScientificWorldJournal. 2014;2014:890151. doi: 10.1155/2014/890151. Epub 2014 Nov 17.

Abstract

Antinociceptive and anti-inflammatory potentials of methanolic extract of Bridelia retusa fruit (BRME) were evaluated against different animal models in rodents. Antinociceptive effects of BRME were assessed in mice using the acetic acid-induced writhing and formalin test. Anti-inflammatory effects of BRME in three different doses, namely, 100, 200, and 400 mg/kg, were evaluated by utilizing different animal models representing various changes associated with inflammation, namely, carrageenan-induced paw oedema, histamine and serotonin-induced paw oedema, arachidonic acid-induced paw oedema, formalin-induced paw oedema, TPA-induced ear oedema, acetic acid-induced vascular permeability, total WBC count in paw fluid, and myeloperoxidase assay. Also BRME was phytochemically evaluated using chromatographic method. The BRME did not exhibit any signs of toxicity up to a dose of 2000 mg/kg. The extract showed statistical significant inhibition of induced nociception and inflammation in dose dependent manner. The higher dose of extract significantly inhibited pain and inflammation against control (P < 0.001). HPLC results revealed the presence of gallic acid and ellagic acid as phytoconstituents in BRME and it was proven as anti-inflammatory agents. The present study scientifically demonstrated the antinociceptive and anti-inflammatory potential of fruit of B. retusa methanolic extract. These effects may be attributed to the presence of polyphenolic phytoconstituents in the extract.

摘要

对余甘子果实甲醇提取物(BRME)的抗伤害感受和抗炎潜力进行了评估,以啮齿动物的不同动物模型为研究对象。采用乙酸诱导扭体试验和福尔马林试验评估BRME对小鼠的抗伤害感受作用。利用代表炎症相关各种变化的不同动物模型,即角叉菜胶诱导的爪肿胀、组胺和5-羟色胺诱导的爪肿胀、花生四烯酸诱导的爪肿胀、福尔马林诱导的爪肿胀、佛波酯诱导的耳肿胀、乙酸诱导的血管通透性、爪液中白细胞总数和髓过氧化物酶测定,评估了BRME三种不同剂量(即100、200和400mg/kg)的抗炎作用。此外,采用色谱法对BRME进行了植物化学评估。BRME在高达2000mg/kg的剂量下未表现出任何毒性迹象。提取物以剂量依赖性方式对诱导的伤害感受和炎症具有统计学上的显著抑制作用。与对照组相比,较高剂量的提取物显著抑制疼痛和炎症(P<0.001)。高效液相色谱结果显示,BRME中存在没食子酸和鞣花酸作为植物成分,且已证明它们具有抗炎作用。本研究科学地证明了余甘子果实甲醇提取物的抗伤害感受和抗炎潜力。这些作用可能归因于提取物中存在的多酚类植物成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f0/4251411/a1401aec8379/TSWJ2014-890151.001.jpg

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