Reyes-Reyes Adonis, Horsten Roland C, Urbach H Paul, Bhattacharya Nandini
Optics Research Group, Faculty of Applied Sciences, Delft University of Technology , Lorentzweg 1, 2628 CJ Delft, The Netherlands.
Anal Chem. 2015 Jan 6;87(1):507-12. doi: 10.1021/ac504235e. Epub 2014 Dec 23.
The acetone concentration exhaled in the breath of three type 1 diabetes patients (two minors and one adult) and one healthy volunteer is studied using a quantum cascade laser-based spectroscopic system. Using the acetone signature between 1150 and 1250 cm(-1) and a multiline fitting method, the concentration variations on the order of parts per billion by volume were measured. Blood glucose and ketone concentrations in blood measurements were performed simultaneously to study their relation with acetone in exhaled breath. We focus on personalized studies to better understand the role of acetone in diabetes. For each volunteer, we performed a series of measurements over a period of time, including overnight fastings of 11 ± 1 h and during ketosis-hyperglycemia events for the minors. Our results highlight the importance of performing personalized studies because the response of the minors to the presence of ketosis was consistent but unique for each individual. Also, our results emphasize the need for performing more studies with T1D minors, because the acetone concentration in the breath of the minors differs, with respect to those reported in the literature, which are based on adults.
使用基于量子级联激光器的光谱系统，对三名1型糖尿病患者（两名未成年人和一名成年人）以及一名健康志愿者呼出气体中的丙酮浓度进行了研究。利用1150至1250厘米（-1）之间的丙酮特征峰和多线拟合方法，测量了体积分数为十亿分之几量级的浓度变化。同时进行血液中的血糖和酮浓度测量，以研究它们与呼出气体中丙酮的关系。我们专注于个性化研究，以更好地理解丙酮在糖尿病中的作用。对于每位志愿者，我们在一段时间内进行了一系列测量，包括11±1小时的夜间禁食以及未成年人的酮症 - 高血糖事件期间的测量。我们的结果突出了进行个性化研究的重要性，因为未成年人对酮症存在的反应是一致的，但每个个体又具有独特性。此外，我们的结果强调了对1型糖尿病未成年人进行更多研究的必要性，因为未成年人呼出气体中的丙酮浓度与基于成年人的文献报道有所不同。
