Lung M L, Chan K H, Lam W P, Kou S K, Choy D, Chan C W, Ng M H
Department of Microbiology, University of Hong Kong.
Oncology. 1989;46(5):310-7. doi: 10.1159/000226739.
Cryosections of nasopharyngeal tissue from 9 patients suspected of having nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) markers in situ to assess virus infection in the nasopharynx. Viral DNA, EB nuclear antigen, and/or early antigens (EA.D and EA.R) were detected in 5 NPC specimens. EBV infection was not confined to the tumor areas of the biopsy specimens. Lymphoid cells and nontumor areas of these specimens contained EBV markers. In addition, nasopharyngeal tissues obtained from 3 of 4 patients in clinical remission for the disease showed evidence of EBV infection.
对9例疑似鼻咽癌（NPC）患者的鼻咽组织冰冻切片进行原位检查，以检测EB病毒（EBV）标志物，从而评估鼻咽部的病毒感染情况。在5例NPC标本中检测到病毒DNA、EB核抗原和/或早期抗原（EA.D和EA.R）。EBV感染并不局限于活检标本的肿瘤区域。这些标本的淋巴细胞和非肿瘤区域含有EBV标志物。此外，4例临床缓解患者中有3例的鼻咽组织显示有EBV感染迹象。
