Dickens P, Srivastava G, Liu Y T
Department of Pathology, University of Hong Kong.
J Clin Pathol. 1992 Jan;45(1):81-2. doi: 10.1136/jcp.45.1.81.
Sixteen cases of nasopharyngeal carcinoma (eight anaplastic and eight well differentiated squamous types) were examined for the presence of human papillomavirus types 16 and 18 genomes using the polymerase chain reaction on paraffin wax embedded biopsy specimens. Although nasopharyngeal carcinoma, particularly the anaplastic type, is strongly associated with Epstein-Barr virus, other factors may be involved in its pathogenesis. No DNA of either human papillomavirus subtype was detected. It is concluded, therefore, that these two "high risk" types of human papillomavirus are not implicated in the pathogenesis of nasopharyngeal carcinoma. The number of cases in this series was small, however, and further studies are warranted using fresh biopsy material and including other viral subtypes.
对16例鼻咽癌（8例间变型和8例高分化鳞状细胞型）进行了研究，采用聚合酶链反应对石蜡包埋活检标本检测人乳头瘤病毒16型和18型基因组的存在情况。虽然鼻咽癌，特别是间变型，与EB病毒密切相关，但其他因素可能参与其发病机制。未检测到任何一种人乳头瘤病毒亚型的DNA。因此得出结论，这两种“高危”型人乳头瘤病毒与鼻咽癌的发病机制无关。然而，本系列病例数较少，有必要使用新鲜活检材料并纳入其他病毒亚型进行进一步研究。
