Gallina G, Cumbo V, Messina P, Caprera V, Lio D, Caruso C
Institute of Clinical Dentistry, University of Palermo, Italy.
Oral Surg Oral Med Oral Pathol. 1989 Aug;68(2):167-70. doi: 10.1016/0030-4220(89)90187-4.
To investigate whether genetic factors linked to the human leukocyte antigens (HLA) might influence individual resistance to recurrent herpes labialis (RHL), we studied the frequencies of HLA-A, -B, and -C antigens in a sample of Sicilian population. The frequency of HLA-B35 was significantly decreased in the patient group (p corrected = 0.018). Consequently, the relative risk of development of RHL in a subject positive for HLA-B35 was 20 times smaller than in a subject who does not bear B35. Furthermore, a study was made of the possible relationship between the presence of HLA-B35 antigen and antibody titers to herpes simplex virus type 1 (HSV-1) in 62 persons affected or not by RHL. Significantly elevated titers to HSV-1 were found in the diseased group (p less than 0.001), but the geometric mean of antibody titers in HLA-B35 positive subjects was not different from that of B35 negative subjects either of RHL-affected or in healthy persons. These data are in a good agreement with the hypothesis that humoral immune responses play a marginal role in the protection from HSV-1 recurrences.
为了研究与人类白细胞抗原（HLA）相关的遗传因素是否会影响个体对复发性唇疱疹（RHL）的抵抗力，我们对西西里人群样本中的HLA - A、- B和 - C抗原频率进行了研究。患者组中HLA - B35的频率显著降低（校正p值 = 0.018）。因此，HLA - B35阳性个体发生RHL的相对风险比不携带B35的个体小20倍。此外，我们对62名受或未受RHL影响的个体进行了研究，以探讨HLA - B35抗原的存在与抗1型单纯疱疹病毒（HSV - 1）抗体滴度之间的可能关系。在患病组中发现HSV - 1抗体滴度显著升高（p < 0.001），但无论是受RHL影响的个体还是健康个体中，HLA - B35阳性受试者的抗体滴度几何平均值与B35阴性受试者并无差异。这些数据与体液免疫反应在预防HSV - 1复发中起次要作用的假设高度一致。
