Department of Nephrology, Hypertension and Family Medicine, Medical University of Łódź, Łódź, Poland.
Department of Laboratory Diagnostics and Clinical Biochemistry, Medical University of Łódź, Łódź, Poland.
Med Sci Monit. 2014 Dec 16;20:2683-8. doi: 10.12659/MSM.890845.
The aim of this cross-sectional study was to examine the relationship between obesity and lipid markers.
We divided 66 non-diabetic adult obese patients (mean age: 55.8±11.6 years) into 3 groups according to body mass index (BMI). All patients were measured for waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI), and visceral adiposity index (VAI). Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were determined, and lipid indices TC/HDL, LDL/HDL, and TG/HDL were also estimated.
TC and LDL-C in Group III were lower than in Group I (5.0±1.0 vs. 6.0±1.0 mmol/L, and 2.9±0.9 vs. 3.8±1.2 mmol/L; p<0.05 for both). Negative correlations were found between: BMI and TC, LDL, and HDL (r=-0.291; r=-0.310, r=-0.240, respectively); and WC, WHR, VAI, and HDL (r=-0.371, r=-0.296, r=-0.376, respectively). Positive correlations were found between WC, WHR, and TG/HDL (r=0.279, r=0.244, respectively) and between VAI and: TC (r=0.327), TG (r=0.885), TC/HDL (r=0.618), LDL/HDL (r=0.480), and TG/HDL (r=0.927).
Obesity is associated with lipid disturbances, especially with HDL-C reduction, in obese non-diabetic patients. VAI is strongly related to lipid profile and thus may be the most valuable obesity index in obese patients with dyslipidemias.
本横断面研究旨在探讨肥胖与血脂标志物之间的关系。
我们根据体重指数（BMI）将 66 名非糖尿病成年肥胖患者（平均年龄：55.8±11.6 岁）分为 3 组。所有患者均测量腰围（WC）、臀围（HC）、体重指数（BMI）、腰臀比（WHR）、腰高比（WHtR）、体脂指数（BAI）和内脏脂肪指数（VAI）。检测血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）水平，并估算血脂指标 TC/HDL、LDL/HDL 和 TG/HDL。
第 III 组的 TC 和 LDL-C 低于第 I 组（5.0±1.0 vs. 6.0±1.0 mmol/L 和 2.9±0.9 vs. 3.8±1.2 mmol/L；均 p<0.05）。BMI 与 TC、LDL 和 HDL 呈负相关（r=-0.291；r=-0.310，r=-0.240），WC、WHR、VAI 和 HDL 呈负相关（r=-0.371，r=-0.296，r=-0.376）。WC、WHR 与 TG/HDL 呈正相关（r=0.279，r=0.244），VAI 与 TC（r=0.327）、TG（r=0.885）、TC/HDL（r=0.618）、LDL/HDL（r=0.480）和 TG/HDL（r=0.927）呈正相关。
肥胖与非糖尿病肥胖患者的血脂紊乱有关，尤其是与 HDL-C 降低有关。VAI 与血脂谱密切相关，因此在伴有血脂异常的肥胖患者中可能是最有价值的肥胖指数。
