Conte Enrico, Fagone Evelina, Fruciano Mary, Gili Elisa, Iemmolo Maria, Vancheri Carlo
Department of Clinical and Molecular Biomedicine, University of Catania, Italy.
Histol Histopathol. 2015 May;30(5):523-9. doi: 10.14670/HH-30.523. Epub 2014 Dec 16.
Resveratrol, a natural polyphenolic molecule with several biological activities, is a well recognized anti-oxidant, anti-aging and cancer chemopreventive agent. Moreover, resveratrol anti-inflammatory and antifibrotic properties have been demonstrated both in vitro and in different animal models of inflammatory pathologies, including bowel and liver diseases. We review the evidence of resveratrol protective role in respiratory diseases such as acute lung injury, asthma, chronic obstructive pulmonary disease and lung fibrosis. We conclude that resveratrol and its derivatives may act as a therapeutic agents in respiratory diseases and pertinent clinical trials should be performed.
白藜芦醇是一种具有多种生物活性的天然多酚分子，是一种公认的抗氧化、抗衰老和癌症化学预防剂。此外，白藜芦醇的抗炎和抗纤维化特性已在体外以及包括肠道和肝脏疾病在内的不同炎症性疾病动物模型中得到证实。我们综述了白藜芦醇在急性肺损伤、哮喘、慢性阻塞性肺疾病和肺纤维化等呼吸系统疾病中保护作用的证据。我们得出结论，白藜芦醇及其衍生物可能作为呼吸系统疾病的治疗剂，应开展相关临床试验。
