Carrington Samantha J, Chakraborty Indranil, Bernard Jenna M L, Mascharak Pradip K
Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
Department of Chemistry, University of California , Berkeley, California 94720, United States.
ACS Med Chem Lett. 2014 Nov 17;5(12):1324-8. doi: 10.1021/ml500399r. eCollection 2014 Dec 11.
A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery.
一种设计的光活性一氧化碳释放分子（光CORM），即面式-[MnBr(CO)3(pbt)]（1，pbt = 2-(2-吡啶基)苯并噻唑），在宽带可见光照射下可促进一氧化碳诱导MDA-MB-231人乳腺癌细胞死亡。由于pbt配体的解离，细胞基质内荧光增强可追踪该光CORM释放一氧化碳的过程。本研究结果表明1具有通过递送一氧化碳根除癌细胞的潜力。
