易感和抗性近交系小鼠品系对仙台病毒感染的肺病毒滴度比较。

Comparison of lung virus titers in susceptible and resistant inbred mouse strains against Sendai virus infection.

作者信息

Itoh T, Saitoh M, Iwai H

机构信息

Central Institute for Experimental Animals, Kawasaki, Japan.

出版信息

Jikken Dobutsu. 1989 Jul;38(3):269-73. doi: 10.1538/expanim1978.38.3_269.

DOI:10.1538/expanim1978.38.3_269

PMID:2551702

Abstract

Susceptibility of inbred mouse strains to Sendai virus (Mol strain) infection was studied. Although some mouse strains showed age differences in susceptibility between 3-to 4-week-old and 7-to 8-week-old mice, such age differences in susceptibility were not observed in susceptible DBA/2N and resistant BALB/cA mice. In 7-to 8-week-old mice, remarkable strain differences were observed in mortality and intensity of the lung lesions, but not in lung virus titers and serum antibody, between resistant BALB/cA and susceptible DBA/2N mice.

摘要

研究了近交系小鼠品系对仙台病毒（Mol株）感染的易感性。虽然一些小鼠品系在3至4周龄和7至8周龄小鼠之间的易感性存在年龄差异，但在易感的DBA/2N小鼠和抗性的BALB/cA小鼠中未观察到这种易感性的年龄差异。在7至8周龄的小鼠中，抗性的BALB/cA小鼠和易感的DBA/2N小鼠在死亡率和肺部病变强度方面存在显著的品系差异，但在肺病毒滴度和血清抗体方面没有差异。