Itoh T, Iwai H, Ueda K
Central Institute for Experimental Animals, Kawasaki, Japan.
J Vet Med Sci. 1991 Apr;53(2):275-9. doi: 10.1292/jvms.53.275.
BALB/cA, DBA/2N and CDF1 (BALB/cA x DBA/2N) mice were inoculated intranasally with the Mol strain of Sendai virus (SV), and their mortality and histopathological lung lesions were compared. BALB/cA and CDF1 were resistant and DBA/2N was susceptible in terms of mortality. The lung lesions of the resistant strains were mild and focal, and limited to the bronchial regions, whereas those of the susceptible stain were severe and diffuse, extending to the alveoli. SV antigen was found mainly in the bronchial epithelium in the resistant strains, but in the susceptible strain, the antigen was found also in many alveolar epithelial cells and alveolar macrophages. SV antigen was detected in neither regenerated bronchial epithelium nor endothelial cells. Tumor necrosis factor (TNF) was detected immunohistologically in edematous perivascular regions and in some mononuclear cells infiltrating to the regions, suggesting that TNF is involved in the development of lung lesions by SV infection in the three mouse strains.
将BALB/cA、DBA/2N和CDF1（BALB/cA×DBA/2N）小鼠经鼻接种仙台病毒（SV）的Mol株，比较它们的死亡率和肺组织病理学损伤。就死亡率而言，BALB/cA和CDF1具有抗性，而DBA/2N易感。抗性品系的肺部损伤轻微且局限，仅限于支气管区域，而易感品系的损伤严重且弥漫，延伸至肺泡。在抗性品系中，SV抗原主要存在于支气管上皮中，但在易感品系中，抗原也存在于许多肺泡上皮细胞和肺泡巨噬细胞中。在再生的支气管上皮和内皮细胞中均未检测到SV抗原。通过免疫组织化学法在血管周围水肿区域和浸润到该区域的一些单核细胞中检测到肿瘤坏死因子（TNF），这表明TNF参与了这三种小鼠品系中SV感染所致肺部损伤的发展过程。
