Ateca Laura B, Dombrowski Stefan C, Silverstein Deborah C
Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
J Am Vet Med Assoc. 2015 Jan 1;246(1):100-4. doi: 10.2460/javma.246.1.100.
To determine whether critically ill hypotensive dogs without hyperlactatemia have the same prognosis as critically ill hypotensive dogs with hyperlactatemia.
Retrospective case series.
67 critically ill dogs with hypotension.
Medical records were searched from January 2006 through December 2011 for dogs that were hospitalized in the intensive care unit and that had hypotension and measurement of blood lactate concentration. Blood lactate concentration, systolic blood pressure, and survival rate were compared between hypotensive dogs with and without hyperlactatemia.
19 of 67 (28%) dogs survived and were discharged from the hospital. Hypotensive dogs without hyperlactatemia had a significantly higher systolic blood pressure and were 3.23 (95% confidence interval, 1.04 to 9.43) times as likely to survive, compared with hypotensive dogs with hyperlactatemia. Age, weight, severity of clinical illness, and duration of hospitalization did not differ significantly between hypotensive dogs with and without hyperlactatemia.
Results suggested that hypotensive dogs without hyperlactatemia had a better prognosis and chance of surviving to hospital discharge than did hypotensive dogs with hyperlactatemia. Because blood lactate concentration was negatively associated with systolic blood pressure and survival probability, it may be a useful metric for determining the prognosis of hypotensive dogs.
确定无高乳酸血症的重症低血压犬与有高乳酸血症的重症低血压犬是否具有相同的预后。
回顾性病例系列研究。
67只重症低血压犬。
检索2006年1月至2011年12月期间在重症监护病房住院且有低血压和血乳酸浓度测量值的犬的病历。比较有和无高乳酸血症的低血压犬之间的血乳酸浓度、收缩压和存活率。
67只犬中有19只（28%）存活并出院。与有高乳酸血症的低血压犬相比，无高乳酸血症的低血压犬收缩压显著更高，存活可能性是其3.23倍（95%置信区间，1.04至9.43）。有和无高乳酸血症的低血压犬在年龄、体重、临床疾病严重程度和住院时间方面无显著差异。
结果表明，无高乳酸血症的低血压犬比有高乳酸血症的低血压犬预后更好，存活至出院的机会更大。由于血乳酸浓度与收缩压和生存概率呈负相关，它可能是确定低血压犬预后的有用指标。
