Department of Otolaryngology, Head & Neck Surgery, the First Hospital, Shanxi Medical University, Taiyuan, Shanxi, China,1.
Cancer Invest. 2015 Mar;33(2):29-33. doi: 10.3109/07357907.2014.988344. Epub 2014 Dec 17.
The pathogenesis of laryngeal cancer (LC) is unclear. Published data indicate that micro RNAs (miRNA) play an important role in the pathogenesis of cancer. This study aims to elucidate the role of miR-193b in the tumor tolerance of LC. High levels of miR-193b were detected in LC cells as well as in the culture supernatant. Interleukin (IL)-10-expressing Mos were detected in the LC tissue-derived single cells. Treating naïve Mos with a miR-193b induced expression of IL-10 in the Mos. Culturing the IL-10(+) Mos with effector CD8(+) T cells resulted in the suppression of CD8(+) T-cell activities.
喉癌（LC）的发病机制尚不清楚。已发表的数据表明 microRNAs（miRNA）在癌症的发病机制中发挥着重要作用。本研究旨在阐明 miR-193b 在 LC 肿瘤耐受中的作用。在 LC 细胞以及培养上清液中均检测到高水平的 miR-193b。在 LC 组织来源的单细胞中检测到表达白细胞介素（IL）-10 的 Mos。用 miR-193b 处理幼稚 Mos 可诱导 Mos 中 IL-10 的表达。将 IL-10(+)Mos 与效应性 CD8(+)T 细胞共培养可导致 CD8(+)T 细胞活性受到抑制。
