Saeed Muhammad, Dabbagh Omar, Al-Muhaizae Muhammad, Dhalaan Hesham, Chedrawi Aziza
Department of Neurosciences, King Faisal Specialist Hospital and RC, Saudi Arabia.
J Coll Physicians Surg Pak. 2014 Nov;24 Suppl 3:S216-8.
Epstein-Barr Virus (EBV) causes a broad spectrum of disease in humans with several clinical syndromes and is ubiquitous, infecting more than 95% of the world's population. Central Nervous System (CNS) disease alone associated with Epstein-Barr virus rarely occurs in previously healthy individuals. Systemic viral illness in children and complications are rare, but may occur. In few cases, it is associated with a variety of CNS and hematological complications like acute disseminated encephalomyelitis, transverse myelitis, neuropsychiatric syndrome, GBS, autoimmune thrombocytopenia and hemolytic anemia and they usually respond to immunotherapy. We report previously healthy boy, who presented with left sided weakness, headache and thrombocytopenia following EBV infection. The thrombocytopenia was resistant to intravenous immunoglobulin and methylprednisolone but responded well to Rituximab.
爱泼斯坦-巴尔病毒（EBV）可导致人类出现多种临床综合征的广泛疾病，且该病毒无处不在，全球超过95%的人口受到感染。仅与爱泼斯坦-巴尔病毒相关的中枢神经系统（CNS）疾病在既往健康的个体中很少发生。儿童全身性病毒感染及并发症很少见，但也可能发生。在少数情况下，它与多种中枢神经系统和血液系统并发症相关，如急性播散性脑脊髓炎、横贯性脊髓炎、神经精神综合征、格林-巴利综合征、自身免疫性血小板减少症和溶血性贫血，这些并发症通常对免疫治疗有反应。我们报告了一名既往健康的男孩，他在感染EBV后出现左侧肢体无力、头痛和血小板减少症。血小板减少症对静脉注射免疫球蛋白和甲泼尼龙耐药，但对利妥昔单抗反应良好。
