Tateoka Yumiko
Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan
J Hum Lact. 2015 Aug;31(3):474-8. doi: 10.1177/0890334414563732. Epub 2014 Dec 17.
Bisphenol A (BPA) is generally considered to be an endocrine disruptor. Previous reports indicate that the BPA content in breast milk is higher than that in serum; however, BPA is considered to be excreted in the urine and not to accumulate in the body.
The current study aimed at evaluating the migration of BPA from a commercially available canned coffee drink in a container that was coated with vinyl chloride resin into breast milk.
Ten women who had breastfed for ≥12 months, were ready to cease breastfeeding, and drank commercially available canned coffee drinks daily were approached to participate. A canned coffee drink in which the can contained vinyl chloride resin was chosen. Samples (5 mL each) of urine and breast milk were collected prior to and after ingestion (1 h, 2 h, 4 h, and 6 h) of a 190-mL canned coffee drink. BPA measurements were conducted using an ELISA kit.
Each 190-mL can of coffee contained 196.9 ng/mL BPA, resulting in 37.4 μg that was consumed in each drink. In breast milk, peak BPA excretion occurred at 1 hour; in urine, excretion occurred rapidly during the first hour, remaining relatively unchanged at 2 hours.
The present results indicate that BPA is excreted into the breast milk in addition to the urine and feces. Therefore, it is important to reduce both direct and indirect dietary BPA intake.
双酚A（BPA）通常被认为是一种内分泌干扰物。先前的报告表明，母乳中的双酚A含量高于血清中的含量；然而，双酚A被认为是通过尿液排出体外，不会在体内蓄积。
本研究旨在评估市售罐装咖啡饮料（其容器涂有氯乙烯树脂）中的双酚A向母乳中的迁移情况。
招募了10名已母乳喂养≥12个月、准备停止母乳喂养且每天饮用市售罐装咖啡饮料的女性参与研究。选择了一种罐体含有氯乙烯树脂的罐装咖啡饮料。在摄入190毫升罐装咖啡饮料之前及之后（1小时、2小时、4小时和6小时）采集尿液和母乳样本（各5毫升）。使用酶联免疫吸附测定试剂盒进行双酚A测量。
每罐190毫升咖啡中含有196.9纳克/毫升的双酚A，即每份饮料中摄入37.4微克。母乳中，双酚A排泄峰值出现在1小时；尿液中，排泄在第1小时迅速发生，在2小时保持相对稳定。
目前的结果表明，双酚A除了通过尿液和粪便排出体外，还会排泄到母乳中。因此，减少直接和间接的膳食双酚A摄入量很重要。
