Hartle Jennifer C, Navas-Acien Ana, Lawrence Robert S
Stanford Prevention Research Center in the Department of Medicine, Stanford University School of Medicine, 1070 Arastradero Road, Suite 100, Palo Alto, CA, USA.
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, USA; Department of Environmental Health Sciences, Columbia University, Mailman School of Public Health, 722 West 168th St., New York, NY, USA.
Environ Res. 2016 Oct;150:375-382. doi: 10.1016/j.envres.2016.06.008. Epub 2016 Jun 28.
Exposure to Bisphenol A (BPA) is ubiquitous and includes dietary and environmental pathways. BPA is rapidly glucuronidated in the body, and both BPA and its conjugates can be readily measured in urine.
To investigate the contribution of canned food and beverages, known sources of BPA contamination, to BPA biomarkers of exposure using dietary and urinary BPA concentration information in a representative sample of the U.S.
We evaluated 7669 NHANES 2003-2008 participants 6 years and older with 24-h dietary recall information and urinary BPA concentrations available. Using linear regression models, we evaluated the associations between recent canned food and beverage consumption and urinary BPA concentrations, adjusting for potential confounders.
We found 9% of our participants consumed one canned food in the past 24h and 2% consumed two or more canned foods. The consumption of one canned food vs. none was associated with 24% (95% CI 1.11, 1.38) higher urinary BPA concentrations. The consumption of two or more canned foods vs. none was associated with 54% (95% CI 1.27, 1.88) higher urinary BPA concentrations. The consumption of one or more of some specific types of canned foods vs. none were associated with higher urinary BPA concentrations: 41% (95% CI 1.23, 1.63) higher BPA for vegetable and fruit, 70% (95% CI 1.18, 2.44) higher for canned pasta, and 229% (95% CI 1.22, 4.30) higher for canned soup. Canned beverages were not associated with urinary BPA concentrations.
Canned food, including some specific types such as canned vegetable and fruit, canned pasta, and canned soup were associated with higher levels of urinary BPA concentrations.
双酚A（BPA）的暴露无处不在，包括饮食和环境途径。BPA在体内迅速与葡萄糖醛酸结合，BPA及其结合物均可在尿液中轻松检测到。
利用美国代表性样本中的饮食和尿液BPA浓度信息，调查已知的BPA污染源即罐装食品和饮料对BPA暴露生物标志物的贡献。
我们评估了7669名2003 - 2008年美国国家健康与营养检查调查（NHANES）中6岁及以上的参与者，他们有24小时饮食回忆信息和尿液BPA浓度数据。使用线性回归模型，我们评估了近期罐装食品和饮料消费与尿液BPA浓度之间的关联，并对潜在混杂因素进行了调整。
我们发现9%的参与者在过去24小时内食用了一种罐装食品，2%的参与者食用了两种或更多罐装食品。食用一种罐装食品与未食用相比，尿液BPA浓度高24%（95%置信区间1.11，1.38）。食用两种或更多罐装食品与未食用相比，尿液BPA浓度高54%（95%置信区间1.27，1.88）。食用某些特定类型的一种或多种罐装食品与未食用相比，尿液BPA浓度更高：蔬菜和水果罐头的BPA高41%（95%置信区间1.23，1.63），罐装面食高70%（95%置信区间1.18，2.44），罐装汤高229%（95%置信区间1.22，4.30）。罐装饮料与尿液BPA浓度无关。
罐装食品，包括一些特定类型，如蔬菜和水果罐头、罐装面食和罐装汤，与较高水平的尿液BPA浓度相关。
