Yang Hai-Yan, Liu Jing, Yang Si-Yu, Wang Hai-Yu, Wang Ya-Dong
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China E-mail :
Asian Pac J Cancer Prev. 2014;15(22):9725-30. doi: 10.7314/apjcp.2014.15.22.9725.
Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure.
To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide.
Meta-analysis on the association between SCE frequency and pesticide exposure was performed with STATA 10.0 software package and Review Manager 5.0.24 in this study.
The overall means of SCE were 7.88 [95% confidence intervals (95%CI): 6.71-9.04] for exposure group and 6.05 (95%CI: 5.13-6.95) for controls, respectively. There was statistically significant difference in the SCE frequency in human peripheral blood lymphocytes between pesticide-exposed groups and control groups, and the summary estimate of weighted mean difference was 1.69 (95%CI: 1.01-2.38). We also observed that pesticide-exposed population had significantly higher SCE frequency than control groups among smokers, nonsmokers, pesticide applicator, pesticide producer, other exposure population and Asian population in stratified analyses.
Data indicate that the SCE frequency in human peripheral blood lymphocytes might be an indicator of early genetic effects for pesticide-exposed populations.
人类外周血淋巴细胞中的姐妹染色单体交换（SCE）是用于评估接触农药后遗传损伤的研究最为广泛的生物标志物之一。
估计接触农药人群外周血淋巴细胞中SCE的合并水平。
本研究使用STATA 10.0软件包和RevMan 5.0.24软件对外周血淋巴细胞SCE频率与农药接触之间的关联进行了荟萃分析。
暴露组SCE的总体均值为7.88[95%置信区间（95%CI）：6.71 - 9.04]，对照组为6.05（95%CI：5.13 - 6.95）。农药暴露组与对照组外周血淋巴细胞SCE频率存在统计学显著差异，加权平均差的汇总估计值为1.69（95%CI：1.01 - 2.38）。分层分析中，我们还观察到在吸烟者、非吸烟者、农药施用者、农药生产者、其他暴露人群和亚洲人群中，农药暴露人群的SCE频率显著高于对照组。
数据表明，外周血淋巴细胞中的SCE频率可能是农药暴露人群早期遗传效应的一个指标。
