Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Department of Radiation Biology & Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Mol Biol Rep. 2023 Jun;50(6):5465-5479. doi: 10.1007/s11033-023-08424-2. Epub 2023 May 8.
Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other industries due to their ability to kill pests. However, OPs can also have genotoxic effects on humans who are exposed to them. This review summarizes the research on DNA damage caused by OPs, the mechanisms behind this damage, and the resulting cellular effects. Even at low doses, OPs have been shown to damage DNA and cause cellular dysfunction. Common phenomena seen in cells that are exposed to OPs include the formation of DNA adducts and lesions, single-strand and double-strand DNA breaks, and DNA and protein inter and intra-cross-links. The present review will aid in comprehending the extent of genetic damage and the impact on DNA repair pathways caused by acute or chronic exposure to OPs. Additionally, understanding the mechanisms of the effects of OPs will aid in correlating them with various diseases, including cancer, Alzheimer's, and Parkinson's disease. Overall, knowledge of the potential adverse effects of different OPs will help in monitoring the health complications they may cause.
有机磷农药 (OPs) 由于能够杀死害虫，因此在农业、医疗保健和其他行业中被广泛使用。然而，接触 OPs 的人也可能受到其遗传毒性影响。这篇综述总结了 OPs 引起的 DNA 损伤、这种损伤背后的机制以及由此产生的细胞效应的研究。即使在低剂量下，OPs 也已被证明会破坏 DNA 并导致细胞功能障碍。暴露于 OPs 的细胞中常见的现象包括 DNA 加合物和损伤的形成、单链和双链 DNA 断裂，以及 DNA 和蛋白质的交联。本综述将有助于理解急性或慢性接触 OPs 引起的遗传损伤程度和对 DNA 修复途径的影响。此外，了解 OPs 影响的机制将有助于将其与包括癌症、阿尔茨海默病和帕金森病在内的各种疾病相关联。总的来说，对不同 OPs 的潜在不良影响的了解将有助于监测它们可能引起的健康并发症。
