一组意大利花卉种植者的细胞遗传学监测：没有证据表明与农药接触有关的DNA损伤。
Cytogenetic monitoring of a group of Italian floriculturists: no evidence of DNA damage related to pesticide exposure.
作者信息
Scarpato R, Migliore L, Angotzi G, Fedi A, Miligi L, Loprieno N
机构信息
Dipartimento di Scienze dell'Ambiente e del Territorio, Università di Pisa, Italy.
出版信息
Mutat Res. 1996 Feb;367(2):73-82. doi: 10.1016/0165-1218(95)00071-2.
The induction of sister chromatid exchanges (SCE), structural chromosome aberrations (CA) or micronuclei (MN) was investigated in peripheral lymphocytes of a group of Italian floriculturists exposed to a mixture of pesticides. No statistically significant difference in the frequencies of cytogenetic damage was detected between exposed and control subjects. Assessment of the effect of confounding factors indicated that smoking affected both SCE and CA frequencies. Multiple regression analysis showed that in heavy smokers (> or = 20 cigarettes/day), SCE and CA levels increased significantly by 17% and 54%, respectively, as compared to non-smokers.
在一组接触农药混合物的意大利花卉种植者的外周血淋巴细胞中，研究了姐妹染色单体交换（SCE）、染色体结构畸变（CA）或微核（MN）的诱导情况。在接触组和对照组之间，未检测到细胞遗传学损伤频率的统计学显著差异。对混杂因素影响的评估表明，吸烟会影响SCE和CA频率。多元回归分析显示，与不吸烟者相比，重度吸烟者（≥20支/天）的SCE和CA水平分别显著增加了17%和54%。
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