用于区分不可分型流感嗜血杆菌与溶血嗜血杆菌的分子工具。
Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus.
作者信息
Pickering Janessa, Richmond Peter C, Kirkham Lea-Ann S
机构信息
School of Paediatrics and Child Health, The University of Western Australia Perth, WA, Australia.
School of Paediatrics and Child Health, The University of Western Australia Perth, WA, Australia ; Centre for Vaccine and Infectious Disease Research, Telethon Kids Institute, The University of Western Australia Perth, WA, Australia.
出版信息
Front Microbiol. 2014 Dec 2;5:664. doi: 10.3389/fmicb.2014.00664. eCollection 2014.
Abstract
Non-typeable Haemophilus influenzae (NTHi) and Haemophilus haemolyticus are closely related bacteria that reside in the upper respiratory tract. NTHi is associated with respiratory tract infections that frequently result in antibiotic prescription whilst H. haemolyticus is rarely associated with disease. NTHi and H. haemolyticus can be indistinguishable by traditional culture methods and molecular differentiation has proven difficult. This current review chronologically summarizes the molecular approaches that have been developed for differentiation of NTHi from H. haemolyticus, highlighting the advantages and disadvantages of each target and/or technique. We also provide suggestions for the development of new tools that would be suitable for clinical and research laboratories.
摘要
不可分型流感嗜血杆菌（NTHi）和溶血嗜血杆菌是寄居在上呼吸道的密切相关细菌。NTHi与常导致抗生素处方的呼吸道感染有关，而溶血嗜血杆菌很少与疾病相关。通过传统培养方法，NTHi和溶血嗜血杆菌可能难以区分，且分子鉴别已证明具有难度。本综述按时间顺序总结了已开发出的用于区分NTHi和溶血嗜血杆菌的分子方法，突出了每个靶点和/或技术的优缺点。我们还为开发适用于临床和研究实验室的新工具提供了建议。
相似文献
1
Molecular tools for differentiation of non-typeable Haemophilus influenzae from Haemophilus haemolyticus.用于区分不可分型流感嗜血杆菌与溶血嗜血杆菌的分子工具。
Front Microbiol. 2014 Dec 2;5:664. doi: 10.3389/fmicb.2014.00664. eCollection 2014.
2
Heme sequestration by hemophilin from reduces respiratory tract colonization and infection with non-typeable .血红素结合蛋白从 中摄取血红素可减少非典型 的呼吸道定植和感染。
mSphere. 2024 Mar 26;9(3):e0000624. doi: 10.1128/msphere.00006-24. Epub 2024 Feb 21.
3
A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae.溶血嗜血杆菌产生的一种血红素结合蛋白可抑制非典型流感嗜血杆菌。
Mol Microbiol. 2020 Feb;113(2):381-398. doi: 10.1111/mmi.14426. Epub 2019 Dec 2.
4
What the pediatrician should know about non-typeable Haemophilus influenzae.儿科医生应该了解的无型流感嗜血杆菌。
J Infect. 2015 Jun;71 Suppl 1:S10-4. doi: 10.1016/j.jinf.2015.04.014. Epub 2015 Apr 25.
5
Comparative Analyses of the Lipooligosaccharides from Nontypeable Haemophilus influenzae and Haemophilus haemolyticus Show Differences in Sialic Acid and Phosphorylcholine Modifications.不可分型流感嗜血杆菌和溶血嗜血杆菌脂寡糖的比较分析显示唾液酸和磷酰胆碱修饰存在差异。
Infect Immun. 2016 Jan 4;84(3):765-74. doi: 10.1128/IAI.01185-15.
6
Haemophilus haemolyticus Interaction with Host Cells Is Different to Nontypeable Haemophilus influenzae and Prevents NTHi Association with Epithelial Cells.溶血嗜血杆菌与宿主细胞的相互作用不同于不可分型流感嗜血杆菌，并可阻止不可分型流感嗜血杆菌与上皮细胞结合。
Front Cell Infect Microbiol. 2016 May 9;6:50. doi: 10.3389/fcimb.2016.00050. eCollection 2016.
7
Prevalence and mechanisms of β-lactam resistance in Haemophilus haemolyticus.溶血嗜血杆菌β-内酰胺类耐药的流行情况及机制。
J Antimicrob Chemother. 2013 May;68(5):1049-53. doi: 10.1093/jac/dks532. Epub 2013 Jan 11.
8
High Prevalence of Non-typeable Haemophilus influenzae and Haemophilus haemolyticus Among Vaccinated Children with Community-Acquired Pneumonia in Vietnam.越南社区获得性肺炎的接种疫苗儿童中不可分型流感嗜血杆菌和溶血嗜血杆菌的高流行率
J Epidemiol Glob Health. 2024 Jun;14(2):498-501. doi: 10.1007/s44197-024-00195-8. Epub 2024 Feb 19.
9
An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae.一株溶血嗜血杆菌产生一种类似细菌素的物质，抑制了非典型流感嗜血杆菌的生长。
Int J Antimicrob Agents. 2017 Apr;49(4):503-506. doi: 10.1016/j.ijantimicag.2016.12.010. Epub 2017 Feb 24.
10
EF-Tu From Non-typeable Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies.非分型流感嗜血杆菌 EF-Tu 是一种免疫原性表面暴露蛋白，可被杀菌抗体靶向。
Front Immunol. 2018 Dec 18;9:2910. doi: 10.3389/fimmu.2018.02910. eCollection 2018.
引用本文的文献
1
Comparative genomic study of non-typeable in children with pneumonia and healthy controls.肺炎患儿与健康对照中非可分型的比较基因组研究。
iScience. 2024 Nov 6;27(12):111330. doi: 10.1016/j.isci.2024.111330. eCollection 2024 Dec 20.
2
Development of DNA Microarray for Parallel Detection of Community-Acquired Pneumonia Bacterial Pathogens.用于社区获得性肺炎细菌病原体并行检测的 DNA 微阵列的开发。
Sovrem Tekhnologii Med. 2024;16(2):16-26. doi: 10.17691/stm2024.16.2.02. Epub 2024 Apr 27.
3
High Prevalence of Non-typeable Haemophilus influenzae and Haemophilus haemolyticus Among Vaccinated Children with Community-Acquired Pneumonia in Vietnam.越南社区获得性肺炎的接种疫苗儿童中不可分型流感嗜血杆菌和溶血嗜血杆菌的高流行率
J Epidemiol Glob Health. 2024 Jun;14(2):498-501. doi: 10.1007/s44197-024-00195-8. Epub 2024 Feb 19.
4
Vaginal carriage of Haemophilus influenzae in a non-pregnant reproductive-age population.非妊娠育龄人群中流感嗜血杆菌的阴道携带情况。
BMC Microbiol. 2023 May 19;23(1):141. doi: 10.1186/s12866-023-02885-y.
5
Whole genome sequencing-based classification of human-related Haemophilus species and detection of antimicrobial resistance genes.基于全基因组测序的人源嗜血杆菌属种分类及抗菌药物耐药基因检测
Genome Med. 2022 Feb 9;14(1):13. doi: 10.1186/s13073-022-01017-x.
6
Oropharyngeal Carriage of -Containing Predicts Lower Prevalence and Density of NTHi Colonisation in Healthy Adults.携带[具体内容未给出]的口咽菌群预示着健康成年人中NTHi定植的较低患病率和密度。
Pathogens. 2021 May 10;10(5):577. doi: 10.3390/pathogens10050577.
7
Nasal Delivery of a Commensal Species Inhibits Nontypeable Haemophilus influenzae Colonization and Delays Onset of Otitis Media in Mice.鼻腔递送共生种可抑制流感嗜血杆菌定植并延迟小鼠中耳炎发病
Infect Immun. 2020 Mar 23;88(4). doi: 10.1128/IAI.00685-19.
8
Comparative Genomic Analysis of Haemophilus haemolyticus and Nontypeable Haemophilus influenzae and a New Testing Scheme for Their Discrimination.溶血嗜血杆菌与不可分型流感嗜血杆菌的比较基因组分析及其鉴别新检测方案
J Clin Microbiol. 2016 Dec;54(12):3010-3017. doi: 10.1128/JCM.01511-16. Epub 2016 Oct 5.
9
Duplex Quantitative PCR Assay for Detection of Haemophilus influenzae That Distinguishes Fucose- and Protein D-Negative Strains.用于检测区分岩藻糖和蛋白D阴性菌株的流感嗜血杆菌的双重定量PCR检测法。
J Clin Microbiol. 2016 Sep;54(9):2380-3. doi: 10.1128/JCM.00982-16. Epub 2016 Jun 22.
10
Haemophilus haemolyticus Interaction with Host Cells Is Different to Nontypeable Haemophilus influenzae and Prevents NTHi Association with Epithelial Cells.溶血嗜血杆菌与宿主细胞的相互作用不同于不可分型流感嗜血杆菌，并可阻止不可分型流感嗜血杆菌与上皮细胞结合。
Front Cell Infect Microbiol. 2016 May 9;6:50. doi: 10.3389/fcimb.2016.00050. eCollection 2016.
本文引用的文献
1
Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure.疾病和携带非典型流感嗜血杆菌分离株的基因组测序确定了离散的种群结构。
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5439-44. doi: 10.1073/pnas.1403353111. Epub 2014 Mar 25.
2
Classification, identification, and clinical significance of Haemophilus and Aggregatibacter species with host specificity for humans.对人类具有宿主特异性的嗜血杆菌属和聚集杆菌属菌种的分类、鉴定及临床意义
Clin Microbiol Rev. 2014 Apr;27(2):214-40. doi: 10.1128/CMR.00103-13.
3
Diversity of nontypeable Haemophilus influenzae strains colonizing Australian Aboriginal and non-Aboriginal children.定植于澳大利亚原住民和非原住民儿童的不可分型流感嗜血杆菌菌株的多样性。
J Clin Microbiol. 2014 May;52(5):1352-7. doi: 10.1128/JCM.03448-13. Epub 2014 Feb 5.
4
A PCR-high-resolution melt assay for rapid differentiation of nontypeable Haemophilus influenzae and Haemophilus haemolyticus.一种用于快速区分非典型流感嗜血杆菌和溶血性嗜血杆菌的 PCR-高分辨率熔解分析。
J Clin Microbiol. 2014 Feb;52(2):663-7. doi: 10.1128/JCM.02191-13. Epub 2013 Dec 4.
5
Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults.成人社区获得性肺炎非典型流感嗜血杆菌的分子流行病学研究。
PLoS One. 2013 Dec 13;8(12):e82515. doi: 10.1371/journal.pone.0082515. eCollection 2013.
6
Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae.与携带和疾病相关的不可分型流感嗜血杆菌中缺乏重要的疫苗和诊断靶点。
Clin Vaccine Immunol. 2014 Feb;21(2):250-2. doi: 10.1128/CVI.00632-13. Epub 2013 Nov 27.
7
Rapid discrimination of Haemophilus influenzae, H. parainfluenzae, and H. haemolyticus by fluorescence in situ hybridization (FISH) and two matrix-assisted laser-desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) platforms.应用荧光原位杂交（FISH）和两种基质辅助激光解吸电离飞行时间质谱（MALDI-TOF-MS）平台快速鉴别流感嗜血杆菌、副流感嗜血杆菌和溶血性嗜血杆菌。
PLoS One. 2013 Apr 30;8(4):e63222. doi: 10.1371/journal.pone.0063222. Print 2013.
8
PCR screening for the N526K substitution in isolates of Haemophilus influenzae and Haemophilus haemolyticus.聚合酶链反应（PCR）筛选流感嗜血杆菌和溶血性嗜血杆菌分离株中的 N526K 取代。
J Antimicrob Chemother. 2013 Oct;68(10):2255-8. doi: 10.1093/jac/dkt189. Epub 2013 May 3.
9
Quantitative fucK gene polymerase chain reaction on sputum and nasopharyngeal secretions to detect Haemophilus influenzae pneumonia.痰和鼻咽分泌物中定量 fucK 基因聚合酶链反应检测流感嗜血杆菌肺炎。
Diagn Microbiol Infect Dis. 2013 Jun;76(2):141-6. doi: 10.1016/j.diagmicrobio.2013.02.015. Epub 2013 Mar 27.
10
MALDI-TOF MS distinctly differentiates nontypable Haemophilus influenzae from Haemophilus haemolyticus.基质辅助激光解吸电离飞行时间质谱技术能够明显地区分非典型流感嗜血杆菌和溶血性嗜血杆菌。
PLoS One. 2013;8(2):e56139. doi: 10.1371/journal.pone.0056139. Epub 2013 Feb 14.
Zotero 插件