利多卡因对大鼠随意皮瓣成活率的影响。
Effects of lidocaine on random skin flap survival in rats.
机构信息
*Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China; †The first Clinical Medical College of Wenzhou Medical University, Wenzhou, China.
出版信息
Dermatol Surg. 2015 Jan;41(1):53-8. doi: 10.1097/DSS.0000000000000241.
BACKGROUND
Use of a random skin flap is common for repairing wounds and for reconstruction. Lidocaine is a traditional local anesthetic that blocks sodium channels and has positive effects on ischemia-reperfusion injury.
OBJECTIVE
To investigate the effects of lidocaine on random skin flap survival in rats.
MATERIALS AND METHODS
McFarlane flaps were established in 20 rats divided into 2 groups. Lidocaine was injected in the lidocaine group, and the same concentration of saline was injected in the control group. The survival area of the flaps was measured on Day 7. Levels of inflammation were evaluated by hematoxylin and eosin (H&E)-stained slices, and superoxide dismutase and malonyldialdehyde contents were examined.
RESULTS
The mean survival area of the flaps in the lidocaine group was significantly larger than that in the control group. Superoxide dismutase activity increased significantly in the lidocaine group compared with that in the control group. Malonyldialdehyde level in the lidocaine group was significantly lower than that in the control group. The H&E-stained slices showed that inflammation was clearly inhibited in the lidocaine group.
CONCLUSION
Lidocaine improved the survival of random skin flaps.
背景
皮瓣游离移植是修复创伤和重建的常用方法。利多卡因是一种传统的局部麻醉剂，可阻断钠离子通道，并对缺血再灌注损伤有积极作用。
目的
探讨利多卡因对大鼠随意皮瓣存活的影响。
材料和方法
在 20 只大鼠中建立 McFarlane 皮瓣，分为 2 组。利多卡因组皮瓣内注射利多卡因，对照组皮瓣内注射相同浓度的生理盐水。第 7 天测量皮瓣的存活面积。苏木精和伊红（H&E）染色切片评估炎症水平，检测超氧化物歧化酶和丙二醛含量。
结果
利多卡因组皮瓣的平均存活面积明显大于对照组。与对照组相比，利多卡因组中超氧化物歧化酶活性显著升高。利多卡因组丙二醛水平明显低于对照组。H&E 染色切片显示，利多卡因组的炎症明显受到抑制。
结论
利多卡因可提高随意皮瓣的成活率。
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