Narayanasamy Krishnasamy, Sanmarkan Abarna Devi, Rajendran Karthick, Annasamy Chezhian, Ramalingam Senthilkumar
Department of Hepatology, Madras Medical College, Rajiv Gandhi Government General Hospital, Chennai, India.
Institute of Internal Medicine, Madras Medical College, Rajiv Gandhi Government General Hospital, Chennai, India.
Prz Gastroenterol. 2016;11(4):263-269. doi: 10.5114/pg.2015.53376. Epub 2016 Feb 26.
Various components of metabolic syndrome have an important role in the pathogenesis of both non-alcoholic fatty liver disease (NAFLD) and psoriasis, suggesting an association between these diseases. However, at present very few studies have reported on the systematic evaluations of the prevalence of NAFLD in patients with psoriasis disorder.
To investigate the prevalence of NAFLD in patients with psoriasis vulgaris. The study also evaluated the parallel relationship between both of the diseases.
Patients over18 years old and with a diagnosis of psoriasis vulgaris at the outpatient unit of Department of Dermatology were considered for enrolment and were followed up by the Department of Hepatology, Madras Medical College. Each and every patient completed a questionnaire, underwent a thorough skin evaluation, and had a right upper quadrant ultrasound and fasting blood workup.
Two hundred and fifty patients were enrolled in the study. The participants were predominantly middle aged (mean: 44.74 ±11.989 years), overweight (average body mass index (BMI): 24.772 ±3.611 kg/m), and male (68%, = 170). The overall prevalence of NAFLD among psoriasis was 45.2%.
Non-alcoholic fatty liver disease is highly prevalent among our cohort of patients with psoriasis, occurring in 45.2% of patients. Comorbidity of NAFLD is highly associated with psoriasis, which emphasises that both diseases may develop simultaneously. Health care providers should be mindful of this association since early evaluation and diagnosis of NAFLD in patients with psoriasis may play a vital role in alleviating the progression of liver disease.
代谢综合征的各个组成部分在非酒精性脂肪性肝病（NAFLD）和银屑病的发病机制中都起着重要作用，这表明这两种疾病之间存在关联。然而，目前很少有研究报道对银屑病患者中NAFLD患病率的系统评估。
调查寻常型银屑病患者中NAFLD的患病率。该研究还评估了这两种疾病之间的平行关系。
考虑纳入在皮肤科门诊诊断为寻常型银屑病且年龄超过18岁的患者，并由马德拉斯医学院肝病科进行随访。每位患者都完成了一份问卷，接受了全面的皮肤评估，并进行了右上腹超声检查和空腹血液检查。
250名患者纳入该研究。参与者主要为中年（平均：44.74±11.989岁），超重（平均体重指数（BMI）：24.772±3.611kg/m²），且以男性为主（68%，n = 170）。银屑病患者中NAFLD的总体患病率为45.2%。
非酒精性脂肪性肝病在我们的银屑病患者队列中高度流行，在45.2%的患者中出现。NAFLD合并症与银屑病高度相关，这强调了这两种疾病可能同时发生。医疗保健提供者应注意这种关联，因为早期评估和诊断银屑病患者中的NAFLD可能在减轻肝病进展方面发挥至关重要的作用。
