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2
Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine.脊髓灰质炎减毒活疫苗（Sabin 3型）减毒的遗传基础
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Nucleic acid sequence of the region of the genome encoding capsid protein VP1 of neurovirulent and attenuated type 3 polioviruses.编码神经毒力型和减毒3型脊髓灰质炎病毒衣壳蛋白VP1的基因组区域的核酸序列。
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2型口服脊髓灰质炎病毒疫苗神经毒力变异株的核苷酸序列

Nucleotide sequence of a neurovirulent variant of the type 2 oral poliovirus vaccine.

作者信息

Pollard S R, Dunn G, Cammack N, Minor P D, Almond J W

机构信息

Department of Microbiology, University of Reading, England.

出版信息

J Virol. 1989 Nov;63(11):4949-51. doi: 10.1128/JVI.63.11.4949-4951.1989.

DOI:10.1128/JVI.63.11.4949-4951.1989
PMID:2552175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC251143/
Abstract

Infectious cDNAs of the Sabin type 2 poliovirus vaccine virus and a vaccine-derived neurovirulent type 2 strain (P2/117) have been cloned in Escherichia coli. Nucleotide sequence analysis revealed that P2/117 differs from the vaccine strain by just 23 point mutations. Three occur in the 5' noncoding region. The remainder result in a total of 5 coding changes located in VP1, VP4, 2B, and 3D. The likely role of these mutations in the evolution to neurovirulence is discussed.

摘要

脊髓灰质炎病毒疫苗株萨宾2型和一株疫苗衍生的2型神经毒力株（P2/117）的感染性cDNA已在大肠杆菌中克隆。核苷酸序列分析显示，P2/117与疫苗株仅存在23个点突变差异。其中3个发生在5'非编码区。其余突变导致位于VP1、VP4、2B和3D的总共5个编码变化。文中讨论了这些突变在向神经毒力进化过程中可能发挥的作用。