University of British Columbia, Division of Endocrinology, Vancouver, British Columbia, Canada.
University of British Columbia, Division of Maternal-Fetal Medicine, Vancouver, British Columbia, Canada.
Can J Diabetes. 2015 Apr;39(2):128-32. doi: 10.1016/j.jcjd.2014.09.007. Epub 2014 Dec 15.
To examine the diagnostic rates of gestational diabetes (GDM) and maternal/fetal outcomes before and after replacement of the Carpenter and Coustan (C&C) criteria with the International Association Diabetes Pregnancy Study Group (IADPSG) criteria.
A retrospective analysis of all pregnancies in 2 separate 6-month cohorts in the province of British Columbia. The first C&C cohort was defined as a 6-month period prior to the introduction of the IADPSG 75 g glucose tolerance test on October 1, 2010. The IADPSG cohort was studied during a 6-month period after the change.
There was a significant increase in rates of GDM when using the IADPSG 75 g criteria, from 7.9% (1838 of 23 211) to 9.4% (2104 of 22 397). There were no significant changes in maternal outcomes when using the IADPSG criteria (caesarean section, induction of labour, perineal laceration, pregnancy-induced hypertension, antepartum hemorrhage >20 weeks or postpartum hospital length of stay). The caesarean section rate was not increased according to multivariate analysis (30.9% vs. 29.7%; p=0.073). There were no significant changes in most fetal outcomes when using the IADPSG criteria (mean gestational age at birth, premature birth, meconium, birth trauma, mean birth weight, large for gestational age, small for gestational age, intrauterine growth restriction), but neonatal hypoglycemia was significantly higher (1.6 % vs. 1.3 %; p=0.007).
The rates of GDM were higher when using the new IADPSG criteria. Overall, all of the maternal and most of the fetal outcomes were similar.
研究在分别用 Carpenter 和 Coustan(C&C)标准和国际妊娠糖尿病协会(IADPSG)标准替换妊娠糖尿病(GDM)的诊断率和母婴/胎儿结局前后的诊断率。
对不列颠哥伦比亚省 2 个独立的 6 个月队列中的所有妊娠进行回顾性分析。第一个 C&C 队列定义为 2010 年 10 月 1 日引入 IADPSG 75g 葡萄糖耐量试验前的 6 个月。在改变后的 6 个月内研究了 IADPSG 队列。
当使用 IADPSG 75g 标准时,GDM 的发生率显著增加,从 7.9%(1838/23211)增加到 9.4%(2104/22397)。当使用 IADPSG 标准时,母婴结局没有显著变化(剖宫产、引产、会阴裂伤、妊娠高血压、产前出血>20 周或产后住院时间)。根据多变量分析,剖宫产率没有增加(30.9%对 29.7%;p=0.073)。当使用 IADPSG 标准时,大多数胎儿结局没有显著变化(出生时的平均胎龄、早产、胎粪、出生创伤、出生体重的平均值、巨大儿、小于胎龄儿、宫内生长受限),但新生儿低血糖显著升高(1.6%对 1.3%;p=0.007)。
使用新的 IADPSG 标准时,GDM 的发生率更高。总的来说,所有的母婴和大多数胎儿的结局都相似。