1] Department of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan [2] Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Department of Electrical and Electronic Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Nat Commun. 2014 Dec 19;5:5898. doi: 10.1038/ncomms6898.
To measure electrophysiological signals from the human body, it is essential to establish stable, gentle and nonallergic contacts between the targeted biological tissue and the electrical probes. However, it is difficult to form a stable interface between the two for long periods, especially when the surface of the biological tissue is wet and/or the tissue exhibits motion. Here we resolve this difficulty by designing and fabricating smart, stress-absorbing electronic devices that can adhere to wet and complex tissue surfaces and allow for reliable, long-term measurements of vital signals. We demonstrate a multielectrode array, which can be attached to the surface of a rat heart, resulting in good conformal contact for more than 3 h. Furthermore, we demonstrate arrays of highly sensitive, stretchable strain sensors using a similar design. Ultra-flexible electronics with enhanced adhesion to tissue could enable future applications in chronic in vivo monitoring of biological signals.
为了测量人体的电生理信号，必须在目标生物组织和电探针之间建立稳定、温和且无过敏反应的接触。然而，很难长时间保持两者之间的稳定界面，特别是当生物组织的表面湿润且/或组织发生运动时。在这里，我们通过设计和制造智能、可吸收应变的电子设备来解决这个难题，这些设备可以黏附在湿润且复杂的组织表面上，并能够可靠地长期测量生命信号。我们展示了一种可以黏附在老鼠心脏表面的多电极阵列，实现了超过 3 小时的良好贴合接触。此外，我们还展示了使用类似设计的高灵敏度、可拉伸应变传感器阵列。具有增强组织附着能力的超灵活电子产品可能会在未来实现对生物信号的慢性体内监测。
