Visscher C M, Lobbezoo F
Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), MOVE Research Institute Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
J Oral Rehabil. 2015 May;42(5):386-99. doi: 10.1111/joor.12263. Epub 2014 Dec 19.
The aim of this study was to describe the current knowledge on the role of heritability in TMD pain through a systematic review of the literature, including familiar aggregation studies and genetic association studies. For the systematic search of the literature, the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines were followed. In total, 21 studies were included in the review, including five familiar aggregation studies and 16 genetic association studies. From both familiar aggregation studies and genetic association studies, modest evidence for the role of heritability in TMD pain was found. The literature mainly suggests genetic contributions from candidate genes that encode proteins involved in the processing of painful stimuli from the serotonergic and catecholaminergic system. This systematic review shows that the evidence for the role of heritability in the development of TMD pain is cumulating.
本研究的目的是通过对文献的系统综述，包括家族聚集性研究和基因关联研究，来描述目前关于遗传力在颞下颌关节紊乱病（TMD）疼痛中作用的认识。为了系统检索文献，遵循了PRISMA（系统评价和Meta分析的首选报告项目）指南。该综述共纳入21项研究，包括5项家族聚集性研究和16项基因关联研究。从家族聚集性研究和基因关联研究中，均发现了遗传力在TMD疼痛中作用的适度证据。文献主要提示候选基因的遗传贡献，这些基因编码参与5-羟色胺能和儿茶酚胺能系统疼痛刺激处理的蛋白质。该系统综述表明，遗传力在TMD疼痛发生中作用的证据正在不断积累。
