Department of Environmental and Biological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Radiation Oncology, North Carolina State University, Raleigh, NC, USA.
Vet Comp Oncol. 2016 Dec;14(4):e158-e170. doi: 10.1111/vco.12129. Epub 2014 Dec 18.
The objective of this study is to determine the rate of toxicity, median survival time (MST) and prognostic factors in dogs with presumed intracranial meningiomas that were treated with stereotactic radiation therapy (SRT). Patient demographics, neurological history, details of SRT plans and response to treatment (including toxicity and survival times) were examined for potential prognostic factors. Overall MST (MST) due to death for any cause was 561 days. There was a mild to moderate exacerbation of neurological symptoms 3-16 weeks following SRT treatments in 11/30 (36.7%) of dogs. This presumed adverse event was treated with corticosteroids, and improvement was seen in most of these dogs. Death within 6 months of treatment as a result of worsening neurologic signs was seen in 4/30 (13.3%) of dogs. Volume of normal brain that received full dose at a prescription of 8Gy × 3 fractions was predictive of death due to neurological problems within this 6-month period.
本研究旨在确定接受立体定向放射治疗（SRT）的疑似颅内脑膜瘤犬的毒性发生率、中位生存时间（MST）和预后因素。检查了患者的人口统计学、神经病史、SRT 计划的详细信息以及对治疗的反应（包括毒性和生存时间），以寻找潜在的预后因素。所有原因导致的总 MST（MST）为 561 天。在 30 只犬中有 11 只（36.7%）在 SRT 治疗后 3-16 周出现神经症状的轻度至中度恶化。这种推测的不良事件用皮质类固醇治疗，大多数犬的症状都有所改善。在治疗后 6 个月内，由于神经症状恶化而死亡的犬有 4 只（13.3%）。在 8Gy×3 个剂量处方中，接受全剂量的正常脑体积与 6 个月内因神经问题导致的死亡相关。
