Beaudart C, Reginster J-Y, Slomian J, Buckinx F, Locquet M, Bruyère O
Department of Public Health, Epidemiology and Health Economics, University of Liége, Belgium.
J Musculoskelet Neuronal Interact. 2014 Dec;14(4):425-31.
In the definition of the European Working Group on Sarcopenia in Older People (EWGSOP), different cut-off limits are proposed for appendicular lean mass, muscle strength and gait speed. Therefore we aimed to examine the variation in prevalence of sarcopenia obtained with these cut-off limits.
Subjects aged 65 years and older were recruited in an outpatient clinic in Belgium and screened for sarcopenia using the EWGSOP definition. Appendicular lean mass was measured by Dual Energy X-Ray Absorptiometry, muscle strength by a hydraulic handgrip dynamometer and gait speed was measured on a 4-meter distance. Two different cut-off points proposed by the EWGSOP were examined for each variable and 8 diagnostic methods were thereby established.
400 subjects were recruited for this study. Prevalence of sarcopenia varied from 9.25% to 18% depending on the cut-offs applied. When stratified by sex, it seems that the variation in prevalence of sarcopenia was mainly attributable to women. This prevalence ranged from 6.58% to 20.2% for women and only from 13.4% to 14.7% for men.
Prevalence of sarcopenia varies widely depending on the EWGSOP cut-off points applied for women. This may limit clinical researches and development of therapeutic strategies in the field of sarcopenia.
在欧洲老年人肌少症工作组（EWGSOP）的定义中，对四肢瘦体重、肌肉力量和步速提出了不同的临界值。因此，我们旨在研究使用这些临界值得出的肌少症患病率的差异。
在比利时的一家门诊诊所招募了65岁及以上的受试者，并使用EWGSOP的定义对肌少症进行筛查。通过双能X线吸收法测量四肢瘦体重，使用液压握力计测量肌肉力量，并在4米的距离上测量步速。对EWGSOP提出的两个不同临界值针对每个变量进行了检验，从而建立了8种诊断方法。
本研究招募了400名受试者。根据所应用的临界值，肌少症的患病率在9.25%至18%之间变化。按性别分层时，肌少症患病率的差异似乎主要归因于女性。女性的患病率在6.58%至20.2%之间，而男性仅在13.4%至14.7%之间。
根据应用于女性的EWGSOP临界值，肌少症的患病率差异很大。这可能会限制肌少症领域的临床研究和治疗策略的开发。
