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Stiff man syndrome: a diagnostic dilemma in a young female with diabetes mellitus and thyroiditis.僵人综合征:一名患有糖尿病和甲状腺炎的年轻女性的诊断难题。
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Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity.对23例僵人综合征患者的回顾:临床分为僵躯干(人)综合征、僵肢综合征和进行性脑脊髓炎伴强直。
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Stiff person syndrome in a Nepalese man with uncontrolled diabetes mellitus and ketonuria: A rare case report.一名患有未控制的糖尿病和酮尿症的尼泊尔男子患僵人综合征:一例罕见病例报告。
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本文引用的文献

1
Rituximab treatment of stiff-person syndrome in a patient with thymoma, diabetes mellitus and autoimmune thyroiditis.利妥昔单抗治疗合并胸腺瘤、糖尿病和自身免疫性甲状腺炎的僵人综合征
J Clin Neurosci. 2010 Mar;17(3):389-91. doi: 10.1016/j.jocn.2009.06.015. Epub 2010 Jan 13.
2
High-dose intravenous immune globulin for stiff-person syndrome.大剂量静脉注射免疫球蛋白治疗僵人综合征。
N Engl J Med. 2001 Dec 27;345(26):1870-6. doi: 10.1056/NEJMoa01167.
3
Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity.对23例僵人综合征患者的回顾:临床分为僵躯干(人)综合征、僵肢综合征和进行性脑脊髓炎伴强直。
J Neurol Neurosurg Psychiatry. 1998 Nov;65(5):633-40. doi: 10.1136/jnnp.65.5.633.
4
Intrathecal baclofen therapy for stiff-man syndrome and progressive encephalomyelopathy with rigidity and myoclonus.鞘内注射巴氯芬治疗僵人综合征及伴有僵硬和肌阵挛的进行性脑脊髓病。
Neurology. 1997 Dec;49(6):1591-7. doi: 10.1212/wnl.49.6.1591.
5
Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.僵人综合征和胰岛素依赖型糖尿病中的谷氨酸脱羧酶自身抗体在表位识别上呈现出异同。
J Immunol. 1996 Jan 15;156(2):818-25.
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Steroid-responsive and dependent stiff-man syndrome: a clinical and electrophysiological study of two cases.
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Stiff-man syndrome updated.僵人综合征最新进展。
Mayo Clin Proc. 1989 Jun;64(6):629-36. doi: 10.1016/s0025-6196(12)65339-7.
8
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.僵人综合征中针对γ-氨基丁酸能神经元和胰腺β细胞的自身抗体。
N Engl J Med. 1990 May 31;322(22):1555-60. doi: 10.1056/NEJM199005313222202.

僵人综合征:一名患有糖尿病和甲状腺炎的年轻女性的诊断难题。

Stiff man syndrome: a diagnostic dilemma in a young female with diabetes mellitus and thyroiditis.

作者信息

Enuh Hilary, Park Michael, Ghodasara Arjun, Arsura Edward, Nfonoyim Jay

机构信息

Department of Medicine, Richmond University Medical Center, Staten Island, NY, USA.

出版信息

Clin Med Insights Case Rep. 2014 Nov 30;7:139-41. doi: 10.4137/CCRep.S16941. eCollection 2014.

DOI:10.4137/CCRep.S16941
PMID:25525403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4251172/
Abstract

Stiff Person Syndrome (SPS), is a very rare neuroimmunologic disorder characterized by progressive muscle pain, rigidity, stiffness, and spasms. It can be very debilitating if misdiagnosed or not recognized in time. Herein we discuss a case of a female in her 20s who presented with an unsteady gait, lower extremity weakness, persistent leg pain, and stiffness few weeks after uncomplicated childbirth. She has type 1 diabetes mellitus (DM) and was diagnosed with thyroiditis in the course of her illness. The triad of thyroiditis, DM, and stiffness with normal neuroimaging in a young female patient is an unusual occurrence.

摘要

僵人综合征(SPS)是一种非常罕见的神经免疫性疾病,其特征为进行性肌肉疼痛、僵硬、强直和痉挛。如果误诊或未及时识别,它可能会使人非常虚弱。在此,我们讨论一例20多岁女性的病例,该患者在顺产几周后出现步态不稳、下肢无力、持续性腿痛和僵硬。她患有1型糖尿病(DM),在病程中被诊断出患有甲状腺炎。在一名年轻女性患者中,甲状腺炎、DM和神经影像学正常的僵硬三联征是一种不寻常的情况。