17型辅助性T细胞细胞因子与肺部免疫
Helper T-cell type 17 cytokines and immunity in the lung.
作者信息
Kolls Jay K
机构信息
Department of Pediatrics, Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
出版信息
Ann Am Thorac Soc. 2014 Dec;11 Suppl 5(Suppl 5):S284-6. doi: 10.1513/AnnalsATS.201403-109AW.
Abstract
The HIV epidemic has clearly demonstrated the critical role CD4(+) T cells play in preventing opportunistic infections in the lung. The types of CD4(+) effector T-cell populations in the lung have significantly expanded over the last 8-10 years with the discovery of helper T type 17 cells, and this review summarizes the field and discusses how these effector cells may be exploited to augment mucosal immunity in the lung.
摘要
艾滋病毒流行已清楚地表明CD4(+) T细胞在预防肺部机会性感染中所起的关键作用。随着辅助性T17细胞的发现，肺部CD4(+) 效应T细胞群体的类型在过去8至10年中显著扩大，本综述总结了该领域的情况，并讨论了如何利用这些效应细胞来增强肺部的黏膜免疫力。
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